L-Selectin (Cd62l) Is Downregulated On Cd4+ And Cd8+ T Lymphocytes Of Hiv-1-Infected Individuals NaÏve For Art

Lia Vassena, Erica Giuliani, Anna Rita Buonomini, Vincenzo Malagnino, Massimo Andreoni, Margherita Doria

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

ABSTRACT: The expression of L-selectin (CD62L) in HIV-1 infection has not been extensively investigated. Here we measured CD62L expression on T-cell subsets of HIV-1-infected individuals naïve for antiretroviral therapy (ART-naïve) or receiving therapy (ART), and seronegative control subjects (HIV-neg).We found reduced frequencies of CD62L cells among CD4 and CD8 T cells from ART-naïve as compared to ART and HIV-neg groups, particularly within naïve and central memory subsets. CD62L expression on T cells inversely correlated with viral load and rapidly increased following ART initiation. Plasma sCD62L levels did not correlate with CD62L expression, being higher in all HIV-1-infected individuals as compared to HIV-neg subjects. Finally, CD62L downregulation was found associated with the expression of the CD38 activation marker in CD8 T cells, but not in CD4 T cells.We suggest that CD62L downregulation due to unconstrained HIV-1 replication may have important consequences for T-cell circulation and function and for disease progression.

Original languageEnglish
JournalJournal of Acquired Immune Deficiency Syndromes
DOIs
Publication statusAccepted/In press - Mar 19 2016

Fingerprint

L-Selectin
Art
Down-Regulation
HIV-1
T-Lymphocytes
HIV
T-Lymphocyte Subsets
Viral Load
HIV Infections
Disease Progression
Therapeutics

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

L-Selectin (Cd62l) Is Downregulated On Cd4+ And Cd8+ T Lymphocytes Of Hiv-1-Infected Individuals NaÏve For Art. / Vassena, Lia; Giuliani, Erica; Rita Buonomini, Anna; Malagnino, Vincenzo; Andreoni, Massimo; Doria, Margherita.

In: Journal of Acquired Immune Deficiency Syndromes, 19.03.2016.

Research output: Contribution to journalArticle

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abstract = "ABSTRACT: The expression of L-selectin (CD62L) in HIV-1 infection has not been extensively investigated. Here we measured CD62L expression on T-cell subsets of HIV-1-infected individuals na{\"i}ve for antiretroviral therapy (ART-na{\"i}ve) or receiving therapy (ART), and seronegative control subjects (HIV-neg).We found reduced frequencies of CD62L cells among CD4 and CD8 T cells from ART-na{\"i}ve as compared to ART and HIV-neg groups, particularly within na{\"i}ve and central memory subsets. CD62L expression on T cells inversely correlated with viral load and rapidly increased following ART initiation. Plasma sCD62L levels did not correlate with CD62L expression, being higher in all HIV-1-infected individuals as compared to HIV-neg subjects. Finally, CD62L downregulation was found associated with the expression of the CD38 activation marker in CD8 T cells, but not in CD4 T cells.We suggest that CD62L downregulation due to unconstrained HIV-1 replication may have important consequences for T-cell circulation and function and for disease progression.",
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AU - Rita Buonomini, Anna

AU - Malagnino, Vincenzo

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AU - Doria, Margherita

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AB - ABSTRACT: The expression of L-selectin (CD62L) in HIV-1 infection has not been extensively investigated. Here we measured CD62L expression on T-cell subsets of HIV-1-infected individuals naïve for antiretroviral therapy (ART-naïve) or receiving therapy (ART), and seronegative control subjects (HIV-neg).We found reduced frequencies of CD62L cells among CD4 and CD8 T cells from ART-naïve as compared to ART and HIV-neg groups, particularly within naïve and central memory subsets. CD62L expression on T cells inversely correlated with viral load and rapidly increased following ART initiation. Plasma sCD62L levels did not correlate with CD62L expression, being higher in all HIV-1-infected individuals as compared to HIV-neg subjects. Finally, CD62L downregulation was found associated with the expression of the CD38 activation marker in CD8 T cells, but not in CD4 T cells.We suggest that CD62L downregulation due to unconstrained HIV-1 replication may have important consequences for T-cell circulation and function and for disease progression.

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