l-Sulpiride in young and elderly negative schizophrenics: Clinical and pharmacokinetic variables

Massimo C. Mauri, Patrizia Leva M., Teresa Coppola, Carlo A. Altamura

Research output: Contribution to journalArticlepeer-review


1. Clinical activity, tolerability and kinetic profile of L-sulpiride (200-300 mg/die p.o.) in relation to age, in 14 chronic schizophrenic in patients diagnosed according to DSM III-R, typed as negative forms, were studied. 2. The drug showed Its efficacy in negative forms of schizophrenia, without any significant difference between negative and positive symptoms even if productive symptom scores were quite low already in pre-treatment condition. 3. No more side effects (anticholinergic and extrapyramidal) in elderly patients compared to young/adult ones were reported. 4. No significant differences between young/adult and elderly patients for the various pharmacokinetic parameters (t 1 2, AUC, Cmax, Tmax, Vd and CI), after acute and multiple dosing, were observed.

Original languageEnglish
Pages (from-to)355-366
Number of pages12
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Issue number2
Publication statusPublished - 1994


  • elderly
  • L-sulpiride
  • negative schizophrenia
  • pharmacokinetics

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology


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