L-Thyroxine therapy induces a fall of thyroid microsomal and thyroglobulin antibodies in idiopathic myxedema and in hypothyroid, but not in euthyroid Hashimoto’s thyroiditis

L. Chiovato, C. Marcocci, S. Mariotti, A. Mori, A. Pinchera

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44 Citations (Scopus)

Abstract

Thyroid microsomal (MAb) and thyroglobulin (TgAb) antibodies were sequentially measured by sensitive and quantitative radioassays in 17 patients with goitrous Hashimoto’s thyroiditis (9 hypothyroid, 8 euthyroid) and in 19 patients with idiopathic myxedema before and at various time intervals up to 24–48 months after the institution of L-thyroxine therapy. Thyroid antibodies were also determined in 5 euthyroid subjects with Hashimoto’s thyroiditis maintained without treatment for a similar period. During L-thyroxine administration a reduction of MAb with respect to the pretreatment level was found in 6 of the 9 (67%) hypothyroid patients with Hashimoto’s thyroiditis and in 16 of the 19 (84%) patients with idiopathic myxedema. The decrease of MAb was highly significant in both groups (p <0.001 and p <0.0001, respectively). A fall of TgAb occurred in 2 of the 3 patients (75%) with hypothyroid Hashimoto’s thyroiditis and in 9 of the 10 (90%, p <0.001) patients with idiopathic myxedema having abnormally elevated pretreatment TgAB levels. No consistent pattern of MAb and TgAb changes was observed in the euthyroid subjects with Hashimoto’s thyroiditis, whether treated or untreated. In the hypothyroid patients with Hashimoto’s thyroiditis a significant association was found between the decrease of MAb and the reduction of goiter size (p <0.05) occurring during L-thyroxine administration. Moreover, the decrease of MAb and TgAb in idiopathic myxedema was greater (p <0.05) in the patients with normalized serum TSH (≤ 4 μU/ml) than in those showing only a partial reduction of serum TSH (> 4 μU/ml) under L-thyroxine. It is suggested that the decrease of thyroid antibodies during L-thyroxine therapy could be due to a reduced antigen availability to the immune system, resulting from a decreased stimulation of thyroid tissue by circulating TSH.

Original languageEnglish
Pages (from-to)299-305
Number of pages7
JournalJournal of Endocrinological Investigation
Volume9
Issue number4
DOIs
Publication statusPublished - 1986

Fingerprint

Myxedema
Hashimoto Disease
Thyroglobulin
Thyroxine
Thyroid Gland
Antibodies
Therapeutics
Immune System
Antigens
thyroid microsomal antibodies

Keywords

  • euthyroidism
  • Hashimoto’s thyroiditis
  • hypothyroidism
  • idiopathic myxedema
  • L-thyroxine therapy
  • Microsomal antibody
  • thyroglobulin antibody

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

@article{77259e4b94a344db932804315bd5ba6d,
title = "L-Thyroxine therapy induces a fall of thyroid microsomal and thyroglobulin antibodies in idiopathic myxedema and in hypothyroid, but not in euthyroid Hashimoto’s thyroiditis",
abstract = "Thyroid microsomal (MAb) and thyroglobulin (TgAb) antibodies were sequentially measured by sensitive and quantitative radioassays in 17 patients with goitrous Hashimoto’s thyroiditis (9 hypothyroid, 8 euthyroid) and in 19 patients with idiopathic myxedema before and at various time intervals up to 24–48 months after the institution of L-thyroxine therapy. Thyroid antibodies were also determined in 5 euthyroid subjects with Hashimoto’s thyroiditis maintained without treatment for a similar period. During L-thyroxine administration a reduction of MAb with respect to the pretreatment level was found in 6 of the 9 (67{\%}) hypothyroid patients with Hashimoto’s thyroiditis and in 16 of the 19 (84{\%}) patients with idiopathic myxedema. The decrease of MAb was highly significant in both groups (p <0.001 and p <0.0001, respectively). A fall of TgAb occurred in 2 of the 3 patients (75{\%}) with hypothyroid Hashimoto’s thyroiditis and in 9 of the 10 (90{\%}, p <0.001) patients with idiopathic myxedema having abnormally elevated pretreatment TgAB levels. No consistent pattern of MAb and TgAb changes was observed in the euthyroid subjects with Hashimoto’s thyroiditis, whether treated or untreated. In the hypothyroid patients with Hashimoto’s thyroiditis a significant association was found between the decrease of MAb and the reduction of goiter size (p <0.05) occurring during L-thyroxine administration. Moreover, the decrease of MAb and TgAb in idiopathic myxedema was greater (p <0.05) in the patients with normalized serum TSH (≤ 4 μU/ml) than in those showing only a partial reduction of serum TSH (> 4 μU/ml) under L-thyroxine. It is suggested that the decrease of thyroid antibodies during L-thyroxine therapy could be due to a reduced antigen availability to the immune system, resulting from a decreased stimulation of thyroid tissue by circulating TSH.",
keywords = "euthyroidism, Hashimoto’s thyroiditis, hypothyroidism, idiopathic myxedema, L-thyroxine therapy, Microsomal antibody, thyroglobulin antibody",
author = "L. Chiovato and C. Marcocci and S. Mariotti and A. Mori and A. Pinchera",
year = "1986",
doi = "10.1007/BF03346932",
language = "English",
volume = "9",
pages = "299--305",
journal = "Journal of Endocrinological Investigation",
issn = "0391-4097",
publisher = "Springer International Publishing",
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TY - JOUR

T1 - L-Thyroxine therapy induces a fall of thyroid microsomal and thyroglobulin antibodies in idiopathic myxedema and in hypothyroid, but not in euthyroid Hashimoto’s thyroiditis

AU - Chiovato, L.

AU - Marcocci, C.

AU - Mariotti, S.

AU - Mori, A.

AU - Pinchera, A.

PY - 1986

Y1 - 1986

N2 - Thyroid microsomal (MAb) and thyroglobulin (TgAb) antibodies were sequentially measured by sensitive and quantitative radioassays in 17 patients with goitrous Hashimoto’s thyroiditis (9 hypothyroid, 8 euthyroid) and in 19 patients with idiopathic myxedema before and at various time intervals up to 24–48 months after the institution of L-thyroxine therapy. Thyroid antibodies were also determined in 5 euthyroid subjects with Hashimoto’s thyroiditis maintained without treatment for a similar period. During L-thyroxine administration a reduction of MAb with respect to the pretreatment level was found in 6 of the 9 (67%) hypothyroid patients with Hashimoto’s thyroiditis and in 16 of the 19 (84%) patients with idiopathic myxedema. The decrease of MAb was highly significant in both groups (p <0.001 and p <0.0001, respectively). A fall of TgAb occurred in 2 of the 3 patients (75%) with hypothyroid Hashimoto’s thyroiditis and in 9 of the 10 (90%, p <0.001) patients with idiopathic myxedema having abnormally elevated pretreatment TgAB levels. No consistent pattern of MAb and TgAb changes was observed in the euthyroid subjects with Hashimoto’s thyroiditis, whether treated or untreated. In the hypothyroid patients with Hashimoto’s thyroiditis a significant association was found between the decrease of MAb and the reduction of goiter size (p <0.05) occurring during L-thyroxine administration. Moreover, the decrease of MAb and TgAb in idiopathic myxedema was greater (p <0.05) in the patients with normalized serum TSH (≤ 4 μU/ml) than in those showing only a partial reduction of serum TSH (> 4 μU/ml) under L-thyroxine. It is suggested that the decrease of thyroid antibodies during L-thyroxine therapy could be due to a reduced antigen availability to the immune system, resulting from a decreased stimulation of thyroid tissue by circulating TSH.

AB - Thyroid microsomal (MAb) and thyroglobulin (TgAb) antibodies were sequentially measured by sensitive and quantitative radioassays in 17 patients with goitrous Hashimoto’s thyroiditis (9 hypothyroid, 8 euthyroid) and in 19 patients with idiopathic myxedema before and at various time intervals up to 24–48 months after the institution of L-thyroxine therapy. Thyroid antibodies were also determined in 5 euthyroid subjects with Hashimoto’s thyroiditis maintained without treatment for a similar period. During L-thyroxine administration a reduction of MAb with respect to the pretreatment level was found in 6 of the 9 (67%) hypothyroid patients with Hashimoto’s thyroiditis and in 16 of the 19 (84%) patients with idiopathic myxedema. The decrease of MAb was highly significant in both groups (p <0.001 and p <0.0001, respectively). A fall of TgAb occurred in 2 of the 3 patients (75%) with hypothyroid Hashimoto’s thyroiditis and in 9 of the 10 (90%, p <0.001) patients with idiopathic myxedema having abnormally elevated pretreatment TgAB levels. No consistent pattern of MAb and TgAb changes was observed in the euthyroid subjects with Hashimoto’s thyroiditis, whether treated or untreated. In the hypothyroid patients with Hashimoto’s thyroiditis a significant association was found between the decrease of MAb and the reduction of goiter size (p <0.05) occurring during L-thyroxine administration. Moreover, the decrease of MAb and TgAb in idiopathic myxedema was greater (p <0.05) in the patients with normalized serum TSH (≤ 4 μU/ml) than in those showing only a partial reduction of serum TSH (> 4 μU/ml) under L-thyroxine. It is suggested that the decrease of thyroid antibodies during L-thyroxine therapy could be due to a reduced antigen availability to the immune system, resulting from a decreased stimulation of thyroid tissue by circulating TSH.

KW - euthyroidism

KW - Hashimoto’s thyroiditis

KW - hypothyroidism

KW - idiopathic myxedema

KW - L-thyroxine therapy

KW - Microsomal antibody

KW - thyroglobulin antibody

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U2 - 10.1007/BF03346932

DO - 10.1007/BF03346932

M3 - Article

VL - 9

SP - 299

EP - 305

JO - Journal of Endocrinological Investigation

JF - Journal of Endocrinological Investigation

SN - 0391-4097

IS - 4

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