L1-CAM and N-CAM: From Adhesion Proteins to Pharmacological Targets

Federico Colombo, Jacopo Meldolesi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

L1 cell adhesion molecule (L1-CAM) and neural cell adhesion molecule (N-CAM), key members of the immunoglobulin-like CAM (Ig-CAM) family, were first recognized to play critical roles in surface interactions of neurons, by binding with each other and with extracellular matrix (ECM) proteins. Subsequently, adhesion was recognized to include signaling due to both activation of β-integrin, with the generation of intracellular cascades, and integration with the surface cytoskeleton. The importance of the two Ig-CAMs was revealed by their activation of the tyrosine kinase receptors of fibroblast growth factor (FGF), epidermal growth factor (EGF), and nerve growth factor (NGF). Based on these complex signaling properties, L1-CAM and N-CAM have become of great potential pharmacological interest in neurons and cancers. Treatment of neurodegenerative disorders and cognitive deficits of neurons is aimed to increase the cell Ig-CAM tone, possibly provided by synthetic/mimetic peptides. In cancer cells, where Ig-CAMs are often overexpressed, the proteins are employed for prognosis. The approaches to therapy are based on protein downregulation, antibodies, and adoptive immunotherapy.

Original languageEnglish
Pages (from-to)769-781
Number of pages13
JournalTrends in Pharmacological Sciences
Volume36
Issue number11
DOIs
Publication statusPublished - Nov 1 2015

Fingerprint

Neural Cell Adhesion Molecule L1
Neural Cell Adhesion Molecules
Cell adhesion
Computer aided manufacturing
Adhesion
Pharmacology
Neurons
Molecules
Immunoglobulins
Adoptive Immunotherapy
Proteins
Fibroblast Growth Factors
Extracellular Matrix Proteins
Chemical activation
Receptor Protein-Tyrosine Kinases
Nerve Growth Factor
Cytoskeleton
Epidermal Growth Factor
Integrins
Neurodegenerative Diseases

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

L1-CAM and N-CAM : From Adhesion Proteins to Pharmacological Targets. / Colombo, Federico; Meldolesi, Jacopo.

In: Trends in Pharmacological Sciences, Vol. 36, No. 11, 01.11.2015, p. 769-781.

Research output: Contribution to journalArticle

Colombo, Federico ; Meldolesi, Jacopo. / L1-CAM and N-CAM : From Adhesion Proteins to Pharmacological Targets. In: Trends in Pharmacological Sciences. 2015 ; Vol. 36, No. 11. pp. 769-781.
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