Lab-on-chip-based platform for fast molecular diagnosis of multidrug-resistant tuberculosis

Andrea M. Cabibbe, Paolo Miotto, Raquel Moure, Fernando Alcaide, Silke Feuerriegel, Gianni Pozzi, Vladislav Nikolayevskyy, Francis Drobniewski, Stefan Niemann, Klaus Reither, Daniela M. Cirillo

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated the performance of the molecular lab-on-chip-based VerePLEX Biosystem for detection of multidrug-resistant tuberculosis (MDR-TB), obtaining a diagnostic accuracy of more than 97.8% compared to sequencing and MTBDRplus assay for Mycobacterium tuberculosis complex and rifampin and isoniazid resistance detection on clinical isolates and smear-positive specimens. The speed, user-friendly interface, and versatility make it suitable for routine laboratory use.

Original languageEnglish
Pages (from-to)3876-3880
Number of pages5
JournalJournal of Clinical Microbiology
Volume53
Issue number12
DOIs
Publication statusPublished - Dec 1 2015

ASJC Scopus subject areas

  • Microbiology (medical)

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