TY - JOUR
T1 - Lab-on-chip-based platform for fast molecular diagnosis of multidrug-resistant tuberculosis
AU - Cabibbe, Andrea M.
AU - Miotto, Paolo
AU - Moure, Raquel
AU - Alcaide, Fernando
AU - Feuerriegel, Silke
AU - Pozzi, Gianni
AU - Nikolayevskyy, Vladislav
AU - Drobniewski, Francis
AU - Niemann, Stefan
AU - Reither, Klaus
AU - Cirillo, Daniela M.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - We evaluated the performance of the molecular lab-on-chip-based VerePLEX Biosystem for detection of multidrug-resistant tuberculosis (MDR-TB), obtaining a diagnostic accuracy of more than 97.8% compared to sequencing and MTBDRplus assay for Mycobacterium tuberculosis complex and rifampin and isoniazid resistance detection on clinical isolates and smear-positive specimens. The speed, user-friendly interface, and versatility make it suitable for routine laboratory use.
AB - We evaluated the performance of the molecular lab-on-chip-based VerePLEX Biosystem for detection of multidrug-resistant tuberculosis (MDR-TB), obtaining a diagnostic accuracy of more than 97.8% compared to sequencing and MTBDRplus assay for Mycobacterium tuberculosis complex and rifampin and isoniazid resistance detection on clinical isolates and smear-positive specimens. The speed, user-friendly interface, and versatility make it suitable for routine laboratory use.
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U2 - 10.1128/JCM1.01824-15
DO - 10.1128/JCM1.01824-15
M3 - Article
AN - SCOPUS:84947736301
VL - 53
SP - 3876
EP - 3880
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
SN - 0095-1137
IS - 12
ER -