Labeling of rat neurons by anti-GluR3 IgG from patients with Rasmussen encephalitis

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Abstract

The authors report the immunocytochemical localization in rat brain of affinity-purified anti-GluR3 (glutamate receptor) antibodies from two patients with Rasmussen encephalitis (RE) and from immunized rabbits. The distribution of immunolabeling was similar using antibodies from rabbits and patients with RE. No electrophysiologic responses were elicited from acutely dissociated kainate-responsive neurons isolated from rat brain when these antibodies were applied. These findings show that anti-GluR3 antibodies purified from patients with RE bind to specific regions of the CNS but do not act through an excitotoxic mechanism.

Original languageEnglish
Pages (from-to)324-327
Number of pages4
JournalNeurology
Volume57
Issue number2
Publication statusPublished - Jul 24 2001

ASJC Scopus subject areas

  • Neuroscience(all)

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