In spite of the hazard due to the radiation exposure, preparation of90Y- and177Lu-labelled radiopharmaceuticals is still mainly performed using manual procedures. In the present study the performance of a commercial automatic synthesizer based on disposable cassettes for the labelling of177Lu- and90Y-DOTA-conjugated biomolecules (namely, DOTATOC and PSMA-617) was evaluatedand compared toamanual and a semiautomatedapproach.Thedose exposure of the operatorswas evaluatedaswell.More than 300 clinical preparations of both90Y- and177Lu-labelled radiopharmaceuticals have been performed using the three different methods. The mean radiochemical yields for90Y-DOTATOC were 96.2 ± 4.9%, 90.3 ± 5.6%, and 82.0 ± 8.4%, while for177Lu- DOTATOC they were 98.3% ± 0.6, 90.8% ± 8.3, and 83.1 ± 5.7% when manual, semiautomated, and automated approaches were used, respectively. The mean doses on the whole hands for yttrium-90 preparations were 0.15 ± 0.4 mSv/GBq, 0.04 ± 0.1 mSv/GBq, and 0.11±0.3mSv/GBq formanual, semiautomated, and automated synthesis, respectively, and for lutetium-177 preparations, they were 0.02 ± 0.008 mSv/GBq, 0.01 ± 0.03 mSv/GBq, and 0.01 ± 0.02mSv/GBq, respectively. In conclusion, the automated approach guaranteed reliable and reproducible preparations of pharmaceutical grade therapeutic radiopharmaceuticals in a decent RCY.The radiation exposure of the operators remained comparable to the manual approach mainly due to the fact that a dedicated shielding was still not available for the system.
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging