Labelling of90Y- and177Lu-DOTA-Bioconjugates for targeted radionuclide Therapy: A comparison among manual, semiautomated, and fully automated synthesis

Michele Iori, Pier C. Capponi, Sara Rubagotti, Luca Rosario Esposizione, Johanna Seemann, Riccardo Pitzschler, Thorsten Dreger, Debora Formisano, Elisa Grassi, Federica Fioroni, Annibale Versari, Mattia Asti

Research output: Contribution to journalArticle

Abstract

In spite of the hazard due to the radiation exposure, preparation of90Y- and177Lu-labelled radiopharmaceuticals is still mainly performed using manual procedures. In the present study the performance of a commercial automatic synthesizer based on disposable cassettes for the labelling of177Lu- and90Y-DOTA-conjugated biomolecules (namely, DOTATOC and PSMA-617) was evaluatedand compared toamanual and a semiautomatedapproach.Thedose exposure of the operatorswas evaluatedaswell.More than 300 clinical preparations of both90Y- and177Lu-labelled radiopharmaceuticals have been performed using the three different methods. The mean radiochemical yields for90Y-DOTATOC were 96.2 ± 4.9%, 90.3 ± 5.6%, and 82.0 ± 8.4%, while for177Lu- DOTATOC they were 98.3% ± 0.6, 90.8% ± 8.3, and 83.1 ± 5.7% when manual, semiautomated, and automated approaches were used, respectively. The mean doses on the whole hands for yttrium-90 preparations were 0.15 ± 0.4 mSv/GBq, 0.04 ± 0.1 mSv/GBq, and 0.11±0.3mSv/GBq formanual, semiautomated, and automated synthesis, respectively, and for lutetium-177 preparations, they were 0.02 ± 0.008 mSv/GBq, 0.01 ± 0.03 mSv/GBq, and 0.01 ± 0.02mSv/GBq, respectively. In conclusion, the automated approach guaranteed reliable and reproducible preparations of pharmaceutical grade therapeutic radiopharmaceuticals in a decent RCY.The radiation exposure of the operators remained comparable to the manual approach mainly due to the fact that a dedicated shielding was still not available for the system.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalContrast Media and Molecular Imaging
Volume2017
DOIs
Publication statusPublished - 2017

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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