Laboratory biomarkers to facilitate differential diagnosis between measles and kawasaki disease in a pediatric emergency room: A retrospective study

Danilo Buonsenso, Giulia Macchiarulo, Maria Chiara Supino, Francesco La Penna, Simona Scateni, Alessandra Marchesi, Antonino Reale, Elena Boccuzzi

Research output: Contribution to journalArticle

Abstract

This retrospective study was conducted to analyze clinical and laboratoristic parameters to individuate specific differences and facilitate differential diagnosis between Measles and Kawasaki Disease (KD) at first evaluation in an emergency room. We found similar clinical features as duration of fever and number of KD criteria (p > 0.5) but significant differences in white blood cell count, neutrophils, CRP and LDH levels (p < 0.001). LDH value ≥ 800 mg/dl had sensibility of 89% and specificity of 90% for Measles while CRP ≥ 3 mg/dl had sensibility 89% and specificity of 85% for KD. The combined use of CRP, LDH and AST showed accuracy of 86.67%.

Original languageEnglish
Article numbere2018033
JournalMediterranean Journal of Hematology and Infectious Diseases
Volume10
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

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Mucocutaneous Lymph Node Syndrome
Measles
Hospital Emergency Service
Differential Diagnosis
Retrospective Studies
Biomarkers
Pediatrics
Leukocyte Count
Neutrophils
Fever

Keywords

  • Kawasaki disease
  • Measles

ASJC Scopus subject areas

  • Hematology
  • Infectious Diseases

Cite this

Laboratory biomarkers to facilitate differential diagnosis between measles and kawasaki disease in a pediatric emergency room : A retrospective study. / Buonsenso, Danilo; Macchiarulo, Giulia; Supino, Maria Chiara; Penna, Francesco La; Scateni, Simona; Marchesi, Alessandra; Reale, Antonino; Boccuzzi, Elena.

In: Mediterranean Journal of Hematology and Infectious Diseases, Vol. 10, No. 1, e2018033, 01.01.2018.

Research output: Contribution to journalArticle

Buonsenso, Danilo ; Macchiarulo, Giulia ; Supino, Maria Chiara ; Penna, Francesco La ; Scateni, Simona ; Marchesi, Alessandra ; Reale, Antonino ; Boccuzzi, Elena. / Laboratory biomarkers to facilitate differential diagnosis between measles and kawasaki disease in a pediatric emergency room : A retrospective study. In: Mediterranean Journal of Hematology and Infectious Diseases. 2018 ; Vol. 10, No. 1.
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