Laboratory evaluation during high-dose vitamin A administration: a randomized study on lung cancer patients after surgical resection

Maurizio Infante; Ugo Pastorino; Giuseppe Chiesa; Ezio Bera; Paola Pisani; Maurizio Valente; Gianni Ravasi

doi:10.1007/BF01613140

Laboratory evaluation during high-dose vitamin A administration: a randomized study on lung cancer patients after surgical resection

Maurizio Infante, Ugo Pastorino, Giuseppe Chiesa, Ezio Bera, Paola Pisani, Maurizio Valente, Gianni Ravasi

Research output: Contribution to journal › Article › peer-review

Abstract

The laboratory findings in patients receiving high-dose vitamin A as adjuvant treatment for stage I lung cancer are here reported. A group of 283 patients were randomized to either treatment with retinyl palmitate (300 000 IU daily for 12 months) or standard followup, and are now evaluable after a median observation period of 28 months. At regular intervals, all the patients underwent a physical examination, chest roentgenogram, blood chemistries, haematological assays, hepatic and renal function tests and determinations of serum triglycerides and cholesterol. Serum transaminase abnormalities were of similar magnitude in cases and controls, while γ-glutamyltransferase levels were abnormally elevated in 69% of the treated patients compared to 39% of controls (mean values 149 vs 57 IU/l at 24 months, P

Original language	English
Pages (from-to)	156-162
Number of pages	7
Journal	Journal of Cancer Research and Clinical Oncology
Volume	117
Issue number	2
DOIs	https://doi.org/10.1007/BF01613140
Publication status	Published - Mar 1991

Keywords

Adjuvant treatment
Chemoprevention
Lung cancer
Retinyl palmitate
Toxicity
Vitamin A

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1007/BF01613140

Cite this

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abstract = "The laboratory findings in patients receiving high-dose vitamin A as adjuvant treatment for stage I lung cancer are here reported. A group of 283 patients were randomized to either treatment with retinyl palmitate (300 000 IU daily for 12 months) or standard followup, and are now evaluable after a median observation period of 28 months. At regular intervals, all the patients underwent a physical examination, chest roentgenogram, blood chemistries, haematological assays, hepatic and renal function tests and determinations of serum triglycerides and cholesterol. Serum transaminase abnormalities were of similar magnitude in cases and controls, while γ-glutamyltransferase levels were abnormally elevated in 69% of the treated patients compared to 39% of controls (mean values 149 vs 57 IU/l at 24 months, P",

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AU - Infante, Maurizio

AU - Pastorino, Ugo

AU - Chiesa, Giuseppe

AU - Bera, Ezio

AU - Pisani, Paola

AU - Valente, Maurizio

AU - Ravasi, Gianni

PY - 1991/3

Y1 - 1991/3

N2 - The laboratory findings in patients receiving high-dose vitamin A as adjuvant treatment for stage I lung cancer are here reported. A group of 283 patients were randomized to either treatment with retinyl palmitate (300 000 IU daily for 12 months) or standard followup, and are now evaluable after a median observation period of 28 months. At regular intervals, all the patients underwent a physical examination, chest roentgenogram, blood chemistries, haematological assays, hepatic and renal function tests and determinations of serum triglycerides and cholesterol. Serum transaminase abnormalities were of similar magnitude in cases and controls, while γ-glutamyltransferase levels were abnormally elevated in 69% of the treated patients compared to 39% of controls (mean values 149 vs 57 IU/l at 24 months, P

AB - The laboratory findings in patients receiving high-dose vitamin A as adjuvant treatment for stage I lung cancer are here reported. A group of 283 patients were randomized to either treatment with retinyl palmitate (300 000 IU daily for 12 months) or standard followup, and are now evaluable after a median observation period of 28 months. At regular intervals, all the patients underwent a physical examination, chest roentgenogram, blood chemistries, haematological assays, hepatic and renal function tests and determinations of serum triglycerides and cholesterol. Serum transaminase abnormalities were of similar magnitude in cases and controls, while γ-glutamyltransferase levels were abnormally elevated in 69% of the treated patients compared to 39% of controls (mean values 149 vs 57 IU/l at 24 months, P

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KW - Chemoprevention

KW - Lung cancer

KW - Retinyl palmitate

KW - Toxicity

KW - Vitamin A

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Laboratory evaluation during high-dose vitamin A administration: a randomized study on lung cancer patients after surgical resection

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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