Abstract
The laboratory findings in patients receiving high-dose vitamin A as adjuvant treatment for stage I lung cancer are here reported. A group of 283 patients were randomized to either treatment with retinyl palmitate (300 000 IU daily for 12 months) or standard followup, and are now evaluable after a median observation period of 28 months. At regular intervals, all the patients underwent a physical examination, chest roentgenogram, blood chemistries, haematological assays, hepatic and renal function tests and determinations of serum triglycerides and cholesterol. Serum transaminase abnormalities were of similar magnitude in cases and controls, while γ-glutamyltransferase levels were abnormally elevated in 69% of the treated patients compared to 39% of controls (mean values 149 vs 57 IU/l at 24 months, P
| Original language | English |
|---|---|
| Pages (from-to) | 156-162 |
| Number of pages | 7 |
| Journal | Journal of Cancer Research and Clinical Oncology |
| Volume | 117 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Mar 1991 |
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Keywords
- Adjuvant treatment
- Chemoprevention
- Lung cancer
- Retinyl palmitate
- Toxicity
- Vitamin A
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Laboratory evaluation during high-dose vitamin A administration : a randomized study on lung cancer patients after surgical resection. / Infante, Maurizio; Pastorino, Ugo; Chiesa, Giuseppe; Bera, Ezio; Pisani, Paola; Valente, Maurizio; Ravasi, Gianni.
In: Journal of Cancer Research and Clinical Oncology, Vol. 117, No. 2, 03.1991, p. 156-162.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Laboratory evaluation during high-dose vitamin A administration
T2 - a randomized study on lung cancer patients after surgical resection
AU - Infante, Maurizio
AU - Pastorino, Ugo
AU - Chiesa, Giuseppe
AU - Bera, Ezio
AU - Pisani, Paola
AU - Valente, Maurizio
AU - Ravasi, Gianni
PY - 1991/3
Y1 - 1991/3
N2 - The laboratory findings in patients receiving high-dose vitamin A as adjuvant treatment for stage I lung cancer are here reported. A group of 283 patients were randomized to either treatment with retinyl palmitate (300 000 IU daily for 12 months) or standard followup, and are now evaluable after a median observation period of 28 months. At regular intervals, all the patients underwent a physical examination, chest roentgenogram, blood chemistries, haematological assays, hepatic and renal function tests and determinations of serum triglycerides and cholesterol. Serum transaminase abnormalities were of similar magnitude in cases and controls, while γ-glutamyltransferase levels were abnormally elevated in 69% of the treated patients compared to 39% of controls (mean values 149 vs 57 IU/l at 24 months, P
AB - The laboratory findings in patients receiving high-dose vitamin A as adjuvant treatment for stage I lung cancer are here reported. A group of 283 patients were randomized to either treatment with retinyl palmitate (300 000 IU daily for 12 months) or standard followup, and are now evaluable after a median observation period of 28 months. At regular intervals, all the patients underwent a physical examination, chest roentgenogram, blood chemistries, haematological assays, hepatic and renal function tests and determinations of serum triglycerides and cholesterol. Serum transaminase abnormalities were of similar magnitude in cases and controls, while γ-glutamyltransferase levels were abnormally elevated in 69% of the treated patients compared to 39% of controls (mean values 149 vs 57 IU/l at 24 months, P
KW - Adjuvant treatment
KW - Chemoprevention
KW - Lung cancer
KW - Retinyl palmitate
KW - Toxicity
KW - Vitamin A
UR - http://www.scopus.com/inward/record.url?scp=0026031549&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026031549&partnerID=8YFLogxK
U2 - 10.1007/BF01613140
DO - 10.1007/BF01613140
M3 - Article
VL - 117
SP - 156
EP - 162
JO - Journal of Cancer Research and Clinical Oncology
JF - Journal of Cancer Research and Clinical Oncology
SN - 0171-5216
IS - 2
ER -