Laboratory management of Crimean-Congo haemorrhagic fever virus infections

Perspectives from two European networks

Barbara Bartolini, Cesare E.M. Gruber, Marion Koopmans, Tatjana Avšič, Sylvia Bino, Iva Christova, Roland Grunow, Roger Hewson, Gulay Korukluoglu, Cinthia Menel Lemos, Ali Mirazimi, Anna Papa, Maria Paz Sanchez-Seco, Aisha V. Sauer, Hervè Zeller, Carla Nisii, Maria Rosaria Capobianchi, Giuseppe Ippolito, Chantal B. Reusken, Antonino Di Caro

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Crimean-Congo haemorrhagic fever virus (CCHFV) is considered an emerging infectious disease threat in the European Union. Since 2000, the incidence and geographic range of confirmed CCHF cases have markedly increased, following changes in the distribution of its main vector, Hyalomma ticks. Aims: To review scientific literature and collect experts’ opinion to analyse relevant aspects of the laboratory management of human CCHF cases and any exposed contacts, as well as identify areas for advancement of international collaborative preparedness and laboratory response plans. Methods: We conducted a literature review on CCHF molecular diagnostics through an online search. Further, we obtained expert opinions on the key laboratory aspects of CCHF diagnosis. Consulted experts were members of two European projects, EMERGE (Efficient response to highly dangerous and emerging pathogens at EU level) and EVDLabNet (Emerging Viral Diseases-Expert Laboratory Network).Results: Consensus was reached on relevant and controversial aspects of CCHF disease with implications for laboratory management of human CCHF cases, including biosafety, diagnostic algorithm and advice to improve lab capabilities. Knowledge on the diffusion of CCHF can be obtained by promoting syndromic approach to infectious diseases diagnosis and by including CCHFV infection in the diagnostic algorithm of severe fevers of unknown origin. Conclusion: No effective vaccine and/or therapeutics are available at present so outbreak response relies on rapid identification and appropriate infection control measures. Frontline hospitals and reference laboratories have a crucial role in the response to a CCHF outbreak, which should integrate laboratory, clinical and public health responses.

Original languageEnglish
Article number1800093
Pages (from-to)1-14
Number of pages14
JournalEurosurveillance
Volume24
Issue number5
DOIs
Publication statusPublished - Jan 31 2019

Fingerprint

Crimean-Congo hemorrhagic fever virus
Virus Diseases
Expert Testimony
Disease Outbreaks
Emerging Communicable Diseases
Fever of Unknown Origin
Hospital Laboratories
Molecular Pathology
Ticks
European Union
Infection Control
Communicable Diseases
Vaccines
Public Health
Incidence

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health
  • Virology

Cite this

Laboratory management of Crimean-Congo haemorrhagic fever virus infections : Perspectives from two European networks. / Bartolini, Barbara; Gruber, Cesare E.M.; Koopmans, Marion; Avšič, Tatjana; Bino, Sylvia; Christova, Iva; Grunow, Roland; Hewson, Roger; Korukluoglu, Gulay; Lemos, Cinthia Menel; Mirazimi, Ali; Papa, Anna; Sanchez-Seco, Maria Paz; Sauer, Aisha V.; Zeller, Hervè; Nisii, Carla; Capobianchi, Maria Rosaria; Ippolito, Giuseppe; Reusken, Chantal B.; Di Caro, Antonino.

In: Eurosurveillance, Vol. 24, No. 5, 1800093, 31.01.2019, p. 1-14.

Research output: Contribution to journalArticle

Bartolini, B, Gruber, CEM, Koopmans, M, Avšič, T, Bino, S, Christova, I, Grunow, R, Hewson, R, Korukluoglu, G, Lemos, CM, Mirazimi, A, Papa, A, Sanchez-Seco, MP, Sauer, AV, Zeller, H, Nisii, C, Capobianchi, MR, Ippolito, G, Reusken, CB & Di Caro, A 2019, 'Laboratory management of Crimean-Congo haemorrhagic fever virus infections: Perspectives from two European networks', Eurosurveillance, vol. 24, no. 5, 1800093, pp. 1-14. https://doi.org/10.2807/1560-7917.ES.2019.24.5.1800093
Bartolini, Barbara ; Gruber, Cesare E.M. ; Koopmans, Marion ; Avšič, Tatjana ; Bino, Sylvia ; Christova, Iva ; Grunow, Roland ; Hewson, Roger ; Korukluoglu, Gulay ; Lemos, Cinthia Menel ; Mirazimi, Ali ; Papa, Anna ; Sanchez-Seco, Maria Paz ; Sauer, Aisha V. ; Zeller, Hervè ; Nisii, Carla ; Capobianchi, Maria Rosaria ; Ippolito, Giuseppe ; Reusken, Chantal B. ; Di Caro, Antonino. / Laboratory management of Crimean-Congo haemorrhagic fever virus infections : Perspectives from two European networks. In: Eurosurveillance. 2019 ; Vol. 24, No. 5. pp. 1-14.
@article{05f54a0e6b774fe48eec8352967bb69c,
title = "Laboratory management of Crimean-Congo haemorrhagic fever virus infections: Perspectives from two European networks",
abstract = "Background: Crimean-Congo haemorrhagic fever virus (CCHFV) is considered an emerging infectious disease threat in the European Union. Since 2000, the incidence and geographic range of confirmed CCHF cases have markedly increased, following changes in the distribution of its main vector, Hyalomma ticks. Aims: To review scientific literature and collect experts’ opinion to analyse relevant aspects of the laboratory management of human CCHF cases and any exposed contacts, as well as identify areas for advancement of international collaborative preparedness and laboratory response plans. Methods: We conducted a literature review on CCHF molecular diagnostics through an online search. Further, we obtained expert opinions on the key laboratory aspects of CCHF diagnosis. Consulted experts were members of two European projects, EMERGE (Efficient response to highly dangerous and emerging pathogens at EU level) and EVDLabNet (Emerging Viral Diseases-Expert Laboratory Network).Results: Consensus was reached on relevant and controversial aspects of CCHF disease with implications for laboratory management of human CCHF cases, including biosafety, diagnostic algorithm and advice to improve lab capabilities. Knowledge on the diffusion of CCHF can be obtained by promoting syndromic approach to infectious diseases diagnosis and by including CCHFV infection in the diagnostic algorithm of severe fevers of unknown origin. Conclusion: No effective vaccine and/or therapeutics are available at present so outbreak response relies on rapid identification and appropriate infection control measures. Frontline hospitals and reference laboratories have a crucial role in the response to a CCHF outbreak, which should integrate laboratory, clinical and public health responses.",
author = "Barbara Bartolini and Gruber, {Cesare E.M.} and Marion Koopmans and Tatjana Avšič and Sylvia Bino and Iva Christova and Roland Grunow and Roger Hewson and Gulay Korukluoglu and Lemos, {Cinthia Menel} and Ali Mirazimi and Anna Papa and Sanchez-Seco, {Maria Paz} and Sauer, {Aisha V.} and Herv{\`e} Zeller and Carla Nisii and Capobianchi, {Maria Rosaria} and Giuseppe Ippolito and Reusken, {Chantal B.} and {Di Caro}, Antonino",
year = "2019",
month = "1",
day = "31",
doi = "10.2807/1560-7917.ES.2019.24.5.1800093",
language = "English",
volume = "24",
pages = "1--14",
journal = "Eurosurveillance",
issn = "1560-7917",
publisher = "European Centre for Disease Prevention and Control (ECDC)",
number = "5",

}

TY - JOUR

T1 - Laboratory management of Crimean-Congo haemorrhagic fever virus infections

T2 - Perspectives from two European networks

AU - Bartolini, Barbara

AU - Gruber, Cesare E.M.

AU - Koopmans, Marion

AU - Avšič, Tatjana

AU - Bino, Sylvia

AU - Christova, Iva

AU - Grunow, Roland

AU - Hewson, Roger

AU - Korukluoglu, Gulay

AU - Lemos, Cinthia Menel

AU - Mirazimi, Ali

AU - Papa, Anna

AU - Sanchez-Seco, Maria Paz

AU - Sauer, Aisha V.

AU - Zeller, Hervè

AU - Nisii, Carla

AU - Capobianchi, Maria Rosaria

AU - Ippolito, Giuseppe

AU - Reusken, Chantal B.

AU - Di Caro, Antonino

PY - 2019/1/31

Y1 - 2019/1/31

N2 - Background: Crimean-Congo haemorrhagic fever virus (CCHFV) is considered an emerging infectious disease threat in the European Union. Since 2000, the incidence and geographic range of confirmed CCHF cases have markedly increased, following changes in the distribution of its main vector, Hyalomma ticks. Aims: To review scientific literature and collect experts’ opinion to analyse relevant aspects of the laboratory management of human CCHF cases and any exposed contacts, as well as identify areas for advancement of international collaborative preparedness and laboratory response plans. Methods: We conducted a literature review on CCHF molecular diagnostics through an online search. Further, we obtained expert opinions on the key laboratory aspects of CCHF diagnosis. Consulted experts were members of two European projects, EMERGE (Efficient response to highly dangerous and emerging pathogens at EU level) and EVDLabNet (Emerging Viral Diseases-Expert Laboratory Network).Results: Consensus was reached on relevant and controversial aspects of CCHF disease with implications for laboratory management of human CCHF cases, including biosafety, diagnostic algorithm and advice to improve lab capabilities. Knowledge on the diffusion of CCHF can be obtained by promoting syndromic approach to infectious diseases diagnosis and by including CCHFV infection in the diagnostic algorithm of severe fevers of unknown origin. Conclusion: No effective vaccine and/or therapeutics are available at present so outbreak response relies on rapid identification and appropriate infection control measures. Frontline hospitals and reference laboratories have a crucial role in the response to a CCHF outbreak, which should integrate laboratory, clinical and public health responses.

AB - Background: Crimean-Congo haemorrhagic fever virus (CCHFV) is considered an emerging infectious disease threat in the European Union. Since 2000, the incidence and geographic range of confirmed CCHF cases have markedly increased, following changes in the distribution of its main vector, Hyalomma ticks. Aims: To review scientific literature and collect experts’ opinion to analyse relevant aspects of the laboratory management of human CCHF cases and any exposed contacts, as well as identify areas for advancement of international collaborative preparedness and laboratory response plans. Methods: We conducted a literature review on CCHF molecular diagnostics through an online search. Further, we obtained expert opinions on the key laboratory aspects of CCHF diagnosis. Consulted experts were members of two European projects, EMERGE (Efficient response to highly dangerous and emerging pathogens at EU level) and EVDLabNet (Emerging Viral Diseases-Expert Laboratory Network).Results: Consensus was reached on relevant and controversial aspects of CCHF disease with implications for laboratory management of human CCHF cases, including biosafety, diagnostic algorithm and advice to improve lab capabilities. Knowledge on the diffusion of CCHF can be obtained by promoting syndromic approach to infectious diseases diagnosis and by including CCHFV infection in the diagnostic algorithm of severe fevers of unknown origin. Conclusion: No effective vaccine and/or therapeutics are available at present so outbreak response relies on rapid identification and appropriate infection control measures. Frontline hospitals and reference laboratories have a crucial role in the response to a CCHF outbreak, which should integrate laboratory, clinical and public health responses.

UR - http://www.scopus.com/inward/record.url?scp=85061146392&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061146392&partnerID=8YFLogxK

U2 - 10.2807/1560-7917.ES.2019.24.5.1800093

DO - 10.2807/1560-7917.ES.2019.24.5.1800093

M3 - Article

VL - 24

SP - 1

EP - 14

JO - Eurosurveillance

JF - Eurosurveillance

SN - 1560-7917

IS - 5

M1 - 1800093

ER -