Laboratory markers of hypercoagulability

M. L. Rossi, P. A. Merlini, D. Ardissino

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Investigations carried out over the last 40 years have demonstrated that coronary artery thrombosis is the critical event underlying myocardial infarction and unstable angina. The existence of a prolonged hypercoagulable state preceding the thrombotic event has been postulated for some time and significant associations have been established between the plasma concentrations of a number of hemostatic variables and the frequency of myocardial infarction. High plasma fibrinogen, factor VII/VIIa, tissue-type plasminogen activator and plasminogen activator inhibitor levels have been associated with at least as great a risk of developing myocardial (re)infarction or sudden death as high cholesterol levels, especially in the young. In the last year more sensitive assays have been developed, and they should allow a precise biochemical definition of hypercoagulable states. The significance of these new assays and their role in defining a hypercoagulable state in different conditions are analyzed.

Original languageEnglish
Pages (from-to)490-494
Number of pages5
JournalItalian Heart Journal
Volume2
Issue number7
Publication statusPublished - 2001

Fingerprint

Thrombophilia
Biomarkers
Myocardial Infarction
Coronary Thrombosis
Plasminogen Inactivators
Factor VIIa
Factor VII
Unstable Angina
Tissue Plasminogen Activator
Hemostatics
Sudden Death
Hypercholesterolemia
Fibrinogen
Coronary Vessels

Keywords

  • Coagulation
  • Coronary artery disease
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Rossi, M. L., Merlini, P. A., & Ardissino, D. (2001). Laboratory markers of hypercoagulability. Italian Heart Journal, 2(7), 490-494.

Laboratory markers of hypercoagulability. / Rossi, M. L.; Merlini, P. A.; Ardissino, D.

In: Italian Heart Journal, Vol. 2, No. 7, 2001, p. 490-494.

Research output: Contribution to journalArticle

Rossi, ML, Merlini, PA & Ardissino, D 2001, 'Laboratory markers of hypercoagulability', Italian Heart Journal, vol. 2, no. 7, pp. 490-494.
Rossi ML, Merlini PA, Ardissino D. Laboratory markers of hypercoagulability. Italian Heart Journal. 2001;2(7):490-494.
Rossi, M. L. ; Merlini, P. A. ; Ardissino, D. / Laboratory markers of hypercoagulability. In: Italian Heart Journal. 2001 ; Vol. 2, No. 7. pp. 490-494.
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