Laboratory medicine for the evaluation of kidney disease: From the fetus to the adult

Michele Mussap, Roberta Degrandi, Diego Gazzolo, Vassilios Fanos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Spectrum of kidney disease could be roughly divided in chronic kidney disease (CKD) and acute kidney injury (AKI). CKD mainly consists of steady or progressive loss of renal function with a slow but continuous decrease in glomerular filtration rate (GFR); AKI, on the other hand, is characterized by tubular necrosis, oliguria and tissue damage. The widespread availability of enabling technologies such as functional genomics and proteomics has accelerated the rate of novel biomarker discovery and therapeutic targets for kidney diseases. CKD has an insidious onset and is generally detected at a time when it is clinically quite advanced; adverse outcomes of CKD can be prevented through early detection and treatment. A growing body of evidences demonstrated that the concentration of plasma cystatin C correlated better with directly measured values for GFR than did plasma creatinine and subtle decrements in GFR are more readily detected by cystatin C than by creatinine. A number of novel biochemical markers for the early and accurate identification of AKI have been proposed and have been discussed in this review.

Original languageEnglish
Title of host publicationInternational Conference on Energy and Development, Environment and Biomedicine - Proceedings
Pages9-20
Number of pages12
Publication statusPublished - 2010
Event4th International Conference on Energy and Development, Environment and Biomedicine, EDEB'10 - Corfu Island, Greece
Duration: Jul 22 2010Jul 25 2010

Other

Other4th International Conference on Energy and Development, Environment and Biomedicine, EDEB'10
CountryGreece
CityCorfu Island
Period7/22/107/25/10

Keywords

  • Acute kidney injury (AKI)
  • Chronic kidney disease (CKD)
  • Cystatin C
  • Glomerular filtration rate (GFR)
  • Kidney injury molecule 1 (KIM-1)
  • Neutrophil gelatinase-associated lipocalin (NGAL)

ASJC Scopus subject areas

  • Energy Engineering and Power Technology
  • Biomedical Engineering
  • Environmental Engineering

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