Laboratory methods in epigenetic epidemiology

Ludovic Barault, Rebecca C. Rancourt

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Epidemiology seeks to identify risk factors for disease and to quantify the association between environmental and lifestyle factors and disease frequency in human populations. Epigenetics may provide mechanistic clues on a cellular and molecular level behind epidemiologic links. Combining these two fields along with collecting relevant biospecimens will aid in understanding the benefits and the limitations of genome-wide and gene-specific approaches in decoding the epigenome and its functional relevance. This chapter addresses the importance of the experimental design, optimal preparation of biological samples in population-based studies, provide an overview of the available techniques to analyze DNA methylation, gene expression and histone modification, and highlight possible pitfalls of these approaches.

Original languageEnglish
Title of host publicationEpigenetic Epidemiology
PublisherSpringer Netherlands
Pages37-56
Number of pages20
ISBN (Print)9789400724952, 9400724942, 9789400724945
DOIs
Publication statusPublished - Nov 1 2014

ASJC Scopus subject areas

  • Medicine(all)

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