Laboratory response of patients with panic and obsessive-compulsive disorders to 35% CO2 challenges

Giampaolo Perna, Angelo Bertani, Cinzia Arancio, Paolo Ronchi, Laura Bellodi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The DSM-III-R anxiety disorders section includes both panic disorder and obsessive-compulsive disorder. To evaluate the relationship between these two disorders, subject responses to inhalation of a 35% CO2 and 65% O2 mixture were assessed. Method: Twenty-three patients with panic disorder, 23 with obsessive-compulsive disorder, 12 with both obsessive- compulsive and panic disorder, and 23 healthy comparison subjects were given a single vital capacity inhalation of 35% CO2 and 65% O2 or a placebo mixture of compressed air. A double-blind, random, crossover design was used. Results: Patients with panic disorder and patients with both panic disorder and obsessive-compulsive disorder showed similar strong anxiogenic reactions to 35% CO2, while patients with obsessive-compulsive disorder alone did not differ from comparison subjects. Conclusions: These results confirm that obsessive-compulsive disorder and panic disorder are two distinct syndromes and that patients with these disorders have different sensitivity to CO2 inhalation.

Original languageEnglish
Pages (from-to)85-89
Number of pages5
JournalAmerican Journal of Psychiatry
Volume152
Issue number1
Publication statusPublished - Jan 1995

ASJC Scopus subject areas

  • Psychiatry and Mental health

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