Labral calcification plays a key role in hip pain and symptoms in femoroacetabular impingement

Giovanni Trisolino, Marta Favero, Dante Dallari, Enrico Tassinari, Francesco Traina, Miguel Otero, Steven R Goldring, Mary B Goldring, Chiara Carubbi, Roberta Ramonda, Stefano Stilli, Brunella Grigolo, Eleonora Olivotto

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Hip osteoarthritis (HOA) is the most common hip disorder and a major cause of disability in the adult population, with an estimated prevalence of end-stage disease and total hip replacement. Thus, the diagnosis, prevention, and treatment of the early stages of the disease in young adults are crucial to reduce the incidence of end-stage HOA. The purpose of this study was to determine whether (1) a relationship among the inflammatory status of labrum and synovium collected from patients with femoroacetabular impingement (FAI) would exist; and (2) to investigate the associations among the histopathological features of joint tissues, the pre-operative symptoms and the post-operative outcomes after arthroscopic surgery.

METHODS: Joint tissues from 21 patients undergoing hip arthroscopy for FAI were collected and their histological and immunohistochemical features were correlated with clinical parameters.

RESULTS: Synovial mononuclear cell infiltration was observed in 25% of FAI patients, inversely correlated with the hip disability and osteoarthritis outcome score (HOOS) pain and function subscales and with the absolute and relative change in total HOOS. All the labral samples showed some pattern of degeneration and 67% of the samples showed calcium deposits. The total labral score was associated with increased CD68 positive cells in the synovium. The presence of labral calcifications, along with the chondral damage worsened the HOOS post-op symptoms (adjusted R-square = 0.76 p = 0.0001).

CONCLUSIONS: Our study reveals a relationship between the histologic labral features, the synovial inflammation, and the cartilage condition at the time of FAI. The presence of labral calcifications, along with the cartilage damage and the synovitis negatively affects the post-operative outcomes in patients with FAI.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalJournal of Orthopaedic Surgery and Research
Issue number1
Publication statusPublished - Feb 28 2020


  • Arthroscopy
  • Calcification
  • Femoroacetabular impingement syndrome
  • Labrum
  • Synovial inflammation


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