Lack of a strong association between HLA class II, tumour necrosis factor and transporter associated with antigen processing gene polymorphisms and virological response to α-interferon treatment in patients with chronic hepatitis C

A. Airoldi, Claudio Zavaglia, E. Silini, C. Tinelli, M. Martinetti, M. Asti, A. Rossini, M. Vangeli, L. Salvaneschi, G. Pinzello

Research output: Contribution to journalArticle

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Abstract

The aim of the study was to investigate whether polymorphisms of the HLA class II, tumour necrosis factor (TNF) and transporter associated with antigen processing (TAP) genes influence the response to α-interferon in patients with chronic hepatitis C. Twenty-seven sustained responders and 55 non-responders to α-interferon monotherapy were investigated. HLA-DRB1, DQA1, DQB1, TNFA, TNFB, TAP1 and TAP2 alleles were determined by PCR-based molecular techniques. Sustained virological response was defined as undetectable serum hepatitis C virus (HCV) RNA for at least 3 years after the end of treatment. Probability (P) values were corrected for the number of alleles tested (Pc). Viral genotype 1b was more frequent in responders than in non-responders (56% vs. 26%, P = 0.009). HLA-DQB1 *02 occurred less frequently in responders than in non-responders (14.8% vs. 29%, Pc not significant). HLA-DRB1*11 and DQB1*0602 were found in 22.2% and 9.3% of responders and in 10.9% and 1.8% of non-responders, respectively (P c not significant). There was no difference in the distribution of TNF alleles in the two groups. Twenty-four (88.8%) responder patients as compared with 34 (61.8%) non-responders were TAP1*0101 homozygous (P c not significant). Thus, in European Caucasoids with chronic hepatitis C, we could not demonstrate a strong association between HLA class II, TNF, and TAP gene polymorphisms and response to interferon treatment.

Original languageEnglish
Pages (from-to)259-265
Number of pages7
JournalEuropean Journal of Immunogenetics
Volume31
Issue number6
DOIs
Publication statusPublished - Dec 2004

Fingerprint

Antigen Presentation
Chronic Hepatitis C
Interferons
HLA-DRB1 Chains
Tumor Necrosis Factor-alpha
Alleles
Genes
Hepacivirus
Therapeutics
Genotype
RNA
Polymerase Chain Reaction
Serum
HLA-DQB1 antigen

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Lack of a strong association between HLA class II, tumour necrosis factor and transporter associated with antigen processing gene polymorphisms and virological response to α-interferon treatment in patients with chronic hepatitis C. / Airoldi, A.; Zavaglia, Claudio; Silini, E.; Tinelli, C.; Martinetti, M.; Asti, M.; Rossini, A.; Vangeli, M.; Salvaneschi, L.; Pinzello, G.

In: European Journal of Immunogenetics, Vol. 31, No. 6, 12.2004, p. 259-265.

Research output: Contribution to journalArticle

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title = "Lack of a strong association between HLA class II, tumour necrosis factor and transporter associated with antigen processing gene polymorphisms and virological response to α-interferon treatment in patients with chronic hepatitis C",
abstract = "The aim of the study was to investigate whether polymorphisms of the HLA class II, tumour necrosis factor (TNF) and transporter associated with antigen processing (TAP) genes influence the response to α-interferon in patients with chronic hepatitis C. Twenty-seven sustained responders and 55 non-responders to α-interferon monotherapy were investigated. HLA-DRB1, DQA1, DQB1, TNFA, TNFB, TAP1 and TAP2 alleles were determined by PCR-based molecular techniques. Sustained virological response was defined as undetectable serum hepatitis C virus (HCV) RNA for at least 3 years after the end of treatment. Probability (P) values were corrected for the number of alleles tested (Pc). Viral genotype 1b was more frequent in responders than in non-responders (56{\%} vs. 26{\%}, P = 0.009). HLA-DQB1 *02 occurred less frequently in responders than in non-responders (14.8{\%} vs. 29{\%}, Pc not significant). HLA-DRB1*11 and DQB1*0602 were found in 22.2{\%} and 9.3{\%} of responders and in 10.9{\%} and 1.8{\%} of non-responders, respectively (P c not significant). There was no difference in the distribution of TNF alleles in the two groups. Twenty-four (88.8{\%}) responder patients as compared with 34 (61.8{\%}) non-responders were TAP1*0101 homozygous (P c not significant). Thus, in European Caucasoids with chronic hepatitis C, we could not demonstrate a strong association between HLA class II, TNF, and TAP gene polymorphisms and response to interferon treatment.",
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AU - Silini, E.

AU - Tinelli, C.

AU - Martinetti, M.

AU - Asti, M.

AU - Rossini, A.

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AU - Salvaneschi, L.

AU - Pinzello, G.

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