Abstract
Several studies demonstrated that aldosterone secretion, by bovine, rat and human glomerulosa cells, is inhibited in vitro by atrial natriuretic factor (ANF). This effect has also been investigated with conflicting results in cells taken from aldosterone-producing tumors. In the present study, atrial natriuretic factor has been tested on aldosteronoma cells obtained from 4 patients with primary aldosteronism. The cells were studied both with perfusion and incubation systems. Aldosterone secretion was stimulated by ACTH, angiotensin II and potassium with or without ANF 10μM. In this study ANF lacked to inhibit either basal and stimulated aldosterone secretion, indicating some alterations of ANF-adrenal interaction in this syndrome.
| Original language | English |
|---|---|
| Pages (from-to) | 13-17 |
| Number of pages | 5 |
| Journal | Journal of Endocrinological Investigation |
| Volume | 12 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1989 |
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Keywords
- ACTH
- aldosterone
- angiotensin II
- atrial natriuretic factor
- potassium
- primary aldosteronism
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Lack of aldosterone inhibition by atrial natriuretic factor in primary aldosteronism : in vitro studies. / Rocco, S.; Opocher, Giuseppe; D’Agostino, D.; Leone, L.; Mantero, F.
In: Journal of Endocrinological Investigation, Vol. 12, No. 1, 1989, p. 13-17.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lack of aldosterone inhibition by atrial natriuretic factor in primary aldosteronism
T2 - in vitro studies
AU - Rocco, S.
AU - Opocher, Giuseppe
AU - D’Agostino, D.
AU - Leone, L.
AU - Mantero, F.
PY - 1989
Y1 - 1989
N2 - Several studies demonstrated that aldosterone secretion, by bovine, rat and human glomerulosa cells, is inhibited in vitro by atrial natriuretic factor (ANF). This effect has also been investigated with conflicting results in cells taken from aldosterone-producing tumors. In the present study, atrial natriuretic factor has been tested on aldosteronoma cells obtained from 4 patients with primary aldosteronism. The cells were studied both with perfusion and incubation systems. Aldosterone secretion was stimulated by ACTH, angiotensin II and potassium with or without ANF 10μM. In this study ANF lacked to inhibit either basal and stimulated aldosterone secretion, indicating some alterations of ANF-adrenal interaction in this syndrome.
AB - Several studies demonstrated that aldosterone secretion, by bovine, rat and human glomerulosa cells, is inhibited in vitro by atrial natriuretic factor (ANF). This effect has also been investigated with conflicting results in cells taken from aldosterone-producing tumors. In the present study, atrial natriuretic factor has been tested on aldosteronoma cells obtained from 4 patients with primary aldosteronism. The cells were studied both with perfusion and incubation systems. Aldosterone secretion was stimulated by ACTH, angiotensin II and potassium with or without ANF 10μM. In this study ANF lacked to inhibit either basal and stimulated aldosterone secretion, indicating some alterations of ANF-adrenal interaction in this syndrome.
KW - ACTH
KW - aldosterone
KW - angiotensin II
KW - atrial natriuretic factor
KW - potassium
KW - primary aldosteronism
UR - http://www.scopus.com/inward/record.url?scp=0024564161&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024564161&partnerID=8YFLogxK
U2 - 10.1007/BF03349905
DO - 10.1007/BF03349905
M3 - Article
VL - 12
SP - 13
EP - 17
JO - Journal of Endocrinological Investigation
JF - Journal of Endocrinological Investigation
SN - 0391-4097
IS - 1
ER -