Lack of aldosterone inhibition by atrial natriuretic factor in primary aldosteronism: in vitro studies

S. Rocco; Giuseppe Opocher; D. D’Agostino; L. Leone; F. Mantero

doi:10.1007/BF03349905

Lack of aldosterone inhibition by atrial natriuretic factor in primary aldosteronism: in vitro studies

S. Rocco, Giuseppe Opocher, D. D’Agostino, L. Leone, F. Mantero

Istituto Oncologico Veneto

Research output: Contribution to journal › Article › peer-review

Abstract

Several studies demonstrated that aldosterone secretion, by bovine, rat and human glomerulosa cells, is inhibited in vitro by atrial natriuretic factor (ANF). This effect has also been investigated with conflicting results in cells taken from aldosterone-producing tumors. In the present study, atrial natriuretic factor has been tested on aldosteronoma cells obtained from 4 patients with primary aldosteronism. The cells were studied both with perfusion and incubation systems. Aldosterone secretion was stimulated by ACTH, angiotensin II and potassium with or without ANF 10μM. In this study ANF lacked to inhibit either basal and stimulated aldosterone secretion, indicating some alterations of ANF-adrenal interaction in this syndrome.

Original language	English
Pages (from-to)	13-17
Number of pages	5
Journal	Journal of Endocrinological Investigation
Volume	12
Issue number	1
DOIs	https://doi.org/10.1007/BF03349905
Publication status	Published - 1989

Keywords

ACTH
aldosterone
angiotensin II
atrial natriuretic factor
potassium
primary aldosteronism

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism

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10.1007/BF03349905

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AU - Leone, L.

AU - Mantero, F.

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