Lack of aldosterone inhibition by atrial natriuretic factor in primary aldosteronism

in vitro studies

S. Rocco, Giuseppe Opocher, D. D’Agostino, L. Leone, F. Mantero

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Several studies demonstrated that aldosterone secretion, by bovine, rat and human glomerulosa cells, is inhibited in vitro by atrial natriuretic factor (ANF). This effect has also been investigated with conflicting results in cells taken from aldosterone-producing tumors. In the present study, atrial natriuretic factor has been tested on aldosteronoma cells obtained from 4 patients with primary aldosteronism. The cells were studied both with perfusion and incubation systems. Aldosterone secretion was stimulated by ACTH, angiotensin II and potassium with or without ANF 10μM. In this study ANF lacked to inhibit either basal and stimulated aldosterone secretion, indicating some alterations of ANF-adrenal interaction in this syndrome.

Original languageEnglish
Pages (from-to)13-17
Number of pages5
JournalJournal of Endocrinological Investigation
Volume12
Issue number1
DOIs
Publication statusPublished - 1989

Fingerprint

Hyperaldosteronism
Atrial Natriuretic Factor
Aldosterone
Angiotensin II
Adrenocorticotropic Hormone
Potassium
Perfusion
In Vitro Techniques
Neoplasms

Keywords

  • ACTH
  • aldosterone
  • angiotensin II
  • atrial natriuretic factor
  • potassium
  • primary aldosteronism

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Lack of aldosterone inhibition by atrial natriuretic factor in primary aldosteronism : in vitro studies. / Rocco, S.; Opocher, Giuseppe; D’Agostino, D.; Leone, L.; Mantero, F.

In: Journal of Endocrinological Investigation, Vol. 12, No. 1, 1989, p. 13-17.

Research output: Contribution to journalArticle

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