Lack of anionic phospholipid calcium binding sites in Duchenne muscular dystrophy

M. Moggio, G. Fagiolari, A. Prelle, A. Gallanti, M. Sciacco, G. Scarlato

Research output: Contribution to journalArticle

Abstract

We studied membrane ultrastructural localization of anionic phospholipids (AP) and sialic acid (SA) calcium binding sites in muscle biopsies from Duchenne muscular dystrophy (DMD) and 3 Becker's muscular dystrophy (BMD) patients using polymyxin B (PXB) and limulus polyphemus (LP) as cytochemical markers. We found that AP calcium binding sites are lacking at muscle cell surface in all DMD muscle tissues, in both intact and degenerating muscle fibers. In BMD, AP have an unusual distribution along plasma membrane. Sialic acid calcium binding sites have the same localization along plasma membrane and basal lamina in DMD, BMD, and control muscles. The absence or alterations of structures involved in calcium binding in DMD and BMD may alter membrane calcium permeability, leading to abnormal Ca2+ influx into cells causing muscle necrosis.

Original languageEnglish
Pages (from-to)325-331
Number of pages7
JournalMuscle and Nerve
Volume15
Issue number3
Publication statusPublished - 1992

Keywords

  • anionic phospholipids sialic acid
  • Becker's muscular dystrophy
  • calcium
  • DMD
  • dystrophin

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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