Lack of association between clomiphene citrate resistance and altered glucose metabolism in patients with polycystic ovary syndrome

P. L. Venturini, V. Remorgida, M. Giordano, C. Carrer, V. Aguggia, L. De Cecco

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Objective: We evaluated the possibility that clomiphene citrate resistance in women with polycystic ovary syndrome might be related to altered glucose metabolism. Methods: Ten women showing constant resistance (no ovulation) to 1250 mg of clomiphene citrate, repeated at least three times in a 1-year period, underwent an insulin and glucose metabolism study by oral glucose tolerance test. Results: No association was found between resistance to clomiphene citrate and altered glucose metabolism whereas the latter was related to body weight. Conclusion: Resistance to clomiphene citrate is not associated with the presence of altered glucose metabolism.

Original languageEnglish
Pages (from-to)103-106
Number of pages4
JournalItalian Journal of Gynaecology and Obstetrics
Issue number3
Publication statusPublished - 1993


ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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