Lack of association between GRIA1 polymorphisms and haplotypes with migraine without aura or response to triptans

Sarah Cargnin, Michele Viana, Daniela Mittino, Giorgio Bellomo, Cristina Tassorelli, Giuseppe Nappi, Pier Luigi Canonico, Salvatore Terrazzino

Research output: Contribution to journalArticle

Abstract

The present study was designed to replicate previous findings reporting a significant association between the rs548294 polymorphism at the glutamate receptor subunit GluR1 gene (GRIA1) and migraine without aura, either as a single marker or in haplotype combination with rs2195450. In addition, the role of GRIA1 polymorphisms and haplotypes was evaluated in migraine patients without aura as predictive factors for consistency in headache response to triptans. Analysis of rs548294 and rs2195450 polymorphisms of GRIA1 was conducted by Real-time PCR allelic discrimination assay in 186 migraine patients without aura and 312 healthy controls, respectively. In the logistic regression analysis adjusted for gender and age, genotype and haplotype frequencies for the two polymorphisms did not significantly differ between migraine patients without aura and controls. In addition, no evidence of association was found between GRIA1 polymorphisms/haplotypes and consistent response to triptans. This study failed to replicate previously reported association between GRIA1 rs548294 and migraine without aura, either as single marker or when analyzed in haplotype combination with rs2195450. In addition, no evidence was found for a relevant role of GRIA1 polymorphisms and haplotypes as modulating factors of headache response to triptans.

Original languageEnglish
Pages (from-to)421-427
Number of pages7
JournalNeurological Sciences
Volume35
Issue number3
DOIs
Publication statusPublished - Mar 2014

Keywords

  • GRIA1
  • Migraine
  • Polymorphisms
  • Response
  • Susceptibility
  • Triptans

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology

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