Lack of association between interleukin-1 alpha rs1800587 polymorphism and Alzheimer's disease in two independent European samples

Alessandro Serretti, Paolo Olgiati, Antonis Politis, Petros Malitas, Diego Albani, Sabrina Dusi, Letizia Polito, Stefania De Mauro, Aikaterini Zisaki, Christina Piperi, Ioannis Liappas, Evangelia Stamouli, Antonis Mailis, Anna Rita Atti, Monica Morri, Manjola Ujkaj, Sara Batelli, Gianluigi Forloni, Costantine R. Soldatos, George N. PapadimitriouDiana De Ronchi, Anastasios Kalofoutis

Research output: Contribution to journalArticle

Abstract

Interleukin-1 (IL1) can contribute to pathophysiology of Alzheimer's disease (AD) by promoting deposition of amyloid-β in the brain. The gene encoding IL1 alpha (IL1A) has a common polymorphism in its 5' regulatory region (rs1800587) with possible functional effects. IL1A T/T genotype has been associated with AD but the overall effect is modest and negative studies have been published. The aim of this study was to investigate the association of the IL1A rs1800587 polymorphism with AD in two independent case-control groups from Greece (Athens) and Italy (Faenza and Granarolo). Preliminary results from the ongoing sample (110 patients with sporadic AD and 130 nonpsychiatric controls) showed no association between IL1A variants and AD, however C/T heterozygotes had more severe depression in AD (Cornell Scale for Depression in Dementia) compared to other genotypes (F = 4.56, d.f = 1, p = 0.037) after controlling for age, illness duration and cognitive impairment (MMSE). Despite the small sample size and the possibility of a false negative finding, our preliminary data support the hypothesis the IL1A rs1800587 variants are not associated with AD. The effect of the IL1A on depressive symptomatology warrants further investigations, however the lack of a gene-dose relationship would suggest a false positive.

Original languageEnglish
Pages (from-to)181-187
Number of pages7
JournalJournal of Alzheimer's Disease
Volume16
Issue number1
DOIs
Publication statusPublished - 2009

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Keywords

  • Alzheimer's disease
  • IL-1A gene
  • Inflammatory cytokines
  • Psychosis

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

Serretti, A., Olgiati, P., Politis, A., Malitas, P., Albani, D., Dusi, S., Polito, L., De Mauro, S., Zisaki, A., Piperi, C., Liappas, I., Stamouli, E., Mailis, A., Atti, A. R., Morri, M., Ujkaj, M., Batelli, S., Forloni, G., Soldatos, C. R., ... Kalofoutis, A. (2009). Lack of association between interleukin-1 alpha rs1800587 polymorphism and Alzheimer's disease in two independent European samples. Journal of Alzheimer's Disease, 16(1), 181-187. https://doi.org/10.3233/JAD-2009-0946