Lack of association between Interleukin-18 gene promoter polymorphisms and onset of Alzheimer's disease

Ludovica Segat, Michele Milanese, Beatrice Arosio, Carlo Vergani, Sergio Crovella

Research output: Contribution to journalArticlepeer-review

Abstract

In our case-control study we analyzed two functional IL18 gene promoter polymorphisms (-137 G/C and -607 C/A) and an additional polymorphism at position -656 (G/T) in Alzheimer patients and healthy controls in order to verify the involvement of these genetic variations in the onset of Alzheimer disease. No significant differences were detected for the three IL18 SNPs between AD patients and controls. The haplotypes distribution also did not show any difference within AD subjects and controls.

Original languageEnglish
Pages (from-to)162-164
Number of pages3
JournalNeurobiology of Aging
Volume31
Issue number1
DOIs
Publication statusPublished - Jan 2010

Keywords

  • Alzheimer
  • IL18
  • Polymorphisms

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Geriatrics and Gerontology

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