Lack of association between maternal antibodies to v3 loop peptides and maternal-infant HIV-1 transmission

Neal A. Halsey, Richard Markham, Britta Wahren, Reginald Boulos, Paolo Rossi, Hans Wigzell

Research output: Contribution to journalArticle

Abstract

Summary: We investigated the association between maternal antibodies to HIV-1 peptides in pregnant women and the acquisition of HIV-1 infection by their offspring. Pregnant HIV-1-infected Haitian women were tested for the presence of antibodies against peptides of 14-17 amino acid length from the V3 loop region of strains Illb and MN. Antibody testing was performed in two separate laboratories by enzyme-linked immunosorbent assay (ELISA). Peptides from four regions of the V3 loop were synthesized in several different laboratories and the purity confirmed by high performance liquid chromatog-raphy (HPLC). The mothers of infants who acquired HIV-1 infections did not differ significantly from the mothers of uninfected infants in the prevalence or concentration of antibodies to any of the 15 peptides evaluated. Additional studies are indicated to determine if neutralizing antibodies or other immunologie parameters are associated with maternal-infant HIV-1 transmission.

Original languageEnglish
Pages (from-to)153-157
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume5
Issue number2
Publication statusPublished - 1992

Keywords

  • Haiti
  • HIV-1
  • Immunity
  • Infants
  • Maternal antibodies
  • Peptide

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)
  • Virology
  • Immunology and Allergy

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