Lack of association between mtDNA haplogroups and Alzheimer's disease in Tuscany

M. Mancuso, M. Nardini, D. Micheli, A. Rocchi, C. Nesti, N. J. Giglioli, L. Petrozzi, C. Rossi, R. Ceravolo, A. Bacci, A. Choub, G. Ricci, G. Tognoni, M. L. Manca, G. Siciliano, L. Murri

Research output: Contribution to journalArticle

Abstract

Mitochondrial DNA (mtDNA) haplogroup-specific polymorphisms were previously related to several neurodegenerative diseases, including Alzheimer's disease (AD). However, the precise role of mtDNA haplogroups in the neurodegenerative cascade leading to AD is still unclear. In this work we have genotyped predefined European mtDNA haplogroups in 209 patients with AD and 191 matched controls. In order to minimise the risk of "genetic contamination", which could lead to false associations between gene markers and disease, we were careful to enrol in the study only patients and controls of clear Tuscan origin (with at least three generations of Tuscanborn relatives). The frequency of the haplogroups did not differ between the two groups, and no correlation with gender, ApoE genotype, age of onset or disease status was observed. Further studies will be required to define the contribution of mtDNA haplogroups, if any, to the pathogenesis of AD. A correct population selection, in order to minimise the risk of genetic contamination, is essential in these studies.

Original languageEnglish
Pages (from-to)142-147
Number of pages6
JournalNeurological Sciences
Volume28
Issue number3
DOIs
Publication statusPublished - Jun 2007

Keywords

  • Alzheimer's disease
  • Haplogroups
  • mtDNA

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Lack of association between mtDNA haplogroups and Alzheimer's disease in Tuscany'. Together they form a unique fingerprint.

  • Cite this

    Mancuso, M., Nardini, M., Micheli, D., Rocchi, A., Nesti, C., Giglioli, N. J., Petrozzi, L., Rossi, C., Ceravolo, R., Bacci, A., Choub, A., Ricci, G., Tognoni, G., Manca, M. L., Siciliano, G., & Murri, L. (2007). Lack of association between mtDNA haplogroups and Alzheimer's disease in Tuscany. Neurological Sciences, 28(3), 142-147. https://doi.org/10.1007/s10072-007-0807-z