Lack of association between obsessive-compulsive disorder and the dopamine D3 receptor gene: Some preliminary considerations

M. Catalano, G. Sciuto, D. Di Bella, E. Novelli, M. Nobile, L. Bellodi

Research output: Contribution to journalArticle

Abstract

Controversial results possibly suggesting an association between Tourette's Syndrome (TS) and excess of homozygosity at a Msc I polymorphism in the Dopamine D3 receptor (DRD3) gene have recently been reported. Since a relationship between Obsessive-Compulsive Disorder (OCD) and Tourette's Syndrome (TS) has been suggested, in this study we assessed the frequency of this 2-allele polymorphism in a sample of 97 OCD patients and in 97 control subjects. No statistically significant differences in allele or genotype frequencies were found. Thus this mutation in the coding sequence of the DRD3 gene is unlikely to confer susceptibility to OCD.

Original languageEnglish
Pages (from-to)253-255
Number of pages3
JournalAmerican Journal of Medical Genetics
Volume54
Issue number3
Publication statusPublished - 1994

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Keywords

  • denaturing gradient gel electrophoresis
  • dopamine receptors
  • homozygosity
  • molecular genetics
  • Tourette's Syndrome

ASJC Scopus subject areas

  • Genetics(clinical)

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