Lack of association between serum immunoreactivity and Chlamydia pneumoniae detection in the human aortic wall

Massimo Porqueddu; Rita Spirito; Alessandro Parolari; Marco Zanobini; Giulio Pompilio; Gianluca Polvani; Francesco Alamanni; Davide Stangalini; Elena Tremoli; Paolo Biglioli

doi:10.1161/01.CIR.0000041626.38101.DB

Lack of association between serum immunoreactivity and Chlamydia pneumoniae detection in the human aortic wall

Massimo Porqueddu, Rita Spirito, Alessandro Parolari, Marco Zanobini, Giulio Pompilio, Gianluca Polvani, Francesco Alamanni, Davide Stangalini, Elena Tremoli, Paolo Biglioli

Research output: Contribution to journal › Article › peer-review

Abstract

Background - Only a few studies have focused the attention on the relation between elevated anti-Chlamydia pneumoniae (CP) antibodies and the detection of CP in the arterial wall. The aim of our study is thus to investigate the relationship between immune response to CP and detection of CP in the aortic walls of patients with abdominal aortic aneurysm. Methods and Results - A specimen of aortic wall was obtained from 102 consecutive patients who underwent abdominal aneurysm repair. The possible presence of CP was studied by polymerase chain reaction and confirmed by nonradioactive DNA hybridization. Antibody response to CP was studied (IgG, IgA titers). We found 33 patients (32.4%) with CP DNA+. No correlation between CP DNA detection and antibody titers was found (IgG P=0.52, IgA P=0.66). High correlation between IgG and IgA titer was observed (P

Original language	English
Pages (from-to)	2647-2648
Number of pages	2
Journal	Circulation
Volume	106
Issue number	21
DOIs	https://doi.org/10.1161/01.CIR.0000041626.38101.DB
Publication status	Published - Nov 19 2002

Keywords

Aorta
Atherosclerosis
Coronary disease
Infection

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

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10.1161/01.CIR.0000041626.38101.DB

Cite this

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title = "Lack of association between serum immunoreactivity and Chlamydia pneumoniae detection in the human aortic wall",

abstract = "Background - Only a few studies have focused the attention on the relation between elevated anti-Chlamydia pneumoniae (CP) antibodies and the detection of CP in the arterial wall. The aim of our study is thus to investigate the relationship between immune response to CP and detection of CP in the aortic walls of patients with abdominal aortic aneurysm. Methods and Results - A specimen of aortic wall was obtained from 102 consecutive patients who underwent abdominal aneurysm repair. The possible presence of CP was studied by polymerase chain reaction and confirmed by nonradioactive DNA hybridization. Antibody response to CP was studied (IgG, IgA titers). We found 33 patients (32.4%) with CP DNA+. No correlation between CP DNA detection and antibody titers was found (IgG P=0.52, IgA P=0.66). High correlation between IgG and IgA titer was observed (P",

keywords = "Aorta, Atherosclerosis, Coronary disease, Infection",

author = "Massimo Porqueddu and Rita Spirito and Alessandro Parolari and Marco Zanobini and Giulio Pompilio and Gianluca Polvani and Francesco Alamanni and Davide Stangalini and Elena Tremoli and Paolo Biglioli",

year = "2002",

month = nov,

day = "19",

doi = "10.1161/01.CIR.0000041626.38101.DB",

language = "English",

volume = "106",

pages = "2647--2648",

journal = "Circulation",

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publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Lack of association between serum immunoreactivity and Chlamydia pneumoniae detection in the human aortic wall

AU - Porqueddu, Massimo

AU - Spirito, Rita

AU - Parolari, Alessandro

AU - Zanobini, Marco

AU - Pompilio, Giulio

AU - Polvani, Gianluca

AU - Alamanni, Francesco

AU - Stangalini, Davide

AU - Tremoli, Elena

AU - Biglioli, Paolo

PY - 2002/11/19

Y1 - 2002/11/19

N2 - Background - Only a few studies have focused the attention on the relation between elevated anti-Chlamydia pneumoniae (CP) antibodies and the detection of CP in the arterial wall. The aim of our study is thus to investigate the relationship between immune response to CP and detection of CP in the aortic walls of patients with abdominal aortic aneurysm. Methods and Results - A specimen of aortic wall was obtained from 102 consecutive patients who underwent abdominal aneurysm repair. The possible presence of CP was studied by polymerase chain reaction and confirmed by nonradioactive DNA hybridization. Antibody response to CP was studied (IgG, IgA titers). We found 33 patients (32.4%) with CP DNA+. No correlation between CP DNA detection and antibody titers was found (IgG P=0.52, IgA P=0.66). High correlation between IgG and IgA titer was observed (P

AB - Background - Only a few studies have focused the attention on the relation between elevated anti-Chlamydia pneumoniae (CP) antibodies and the detection of CP in the arterial wall. The aim of our study is thus to investigate the relationship between immune response to CP and detection of CP in the aortic walls of patients with abdominal aortic aneurysm. Methods and Results - A specimen of aortic wall was obtained from 102 consecutive patients who underwent abdominal aneurysm repair. The possible presence of CP was studied by polymerase chain reaction and confirmed by nonradioactive DNA hybridization. Antibody response to CP was studied (IgG, IgA titers). We found 33 patients (32.4%) with CP DNA+. No correlation between CP DNA detection and antibody titers was found (IgG P=0.52, IgA P=0.66). High correlation between IgG and IgA titer was observed (P

KW - Aorta

KW - Atherosclerosis

KW - Coronary disease

KW - Infection

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DO - 10.1161/01.CIR.0000041626.38101.DB

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VL - 106

SP - 2647

EP - 2648

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 21

ER -

Lack of association between serum immunoreactivity and Chlamydia pneumoniae detection in the human aortic wall

Abstract

Keywords

ASJC Scopus subject areas

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