Abstract
Background - Only a few studies have focused the attention on the relation between elevated anti-Chlamydia pneumoniae (CP) antibodies and the detection of CP in the arterial wall. The aim of our study is thus to investigate the relationship between immune response to CP and detection of CP in the aortic walls of patients with abdominal aortic aneurysm. Methods and Results - A specimen of aortic wall was obtained from 102 consecutive patients who underwent abdominal aneurysm repair. The possible presence of CP was studied by polymerase chain reaction and confirmed by nonradioactive DNA hybridization. Antibody response to CP was studied (IgG, IgA titers). We found 33 patients (32.4%) with CP DNA+. No correlation between CP DNA detection and antibody titers was found (IgG P=0.52, IgA P=0.66). High correlation between IgG and IgA titer was observed (P
| Original language | English |
|---|---|
| Pages (from-to) | 2647-2648 |
| Number of pages | 2 |
| Journal | Circulation |
| Volume | 106 |
| Issue number | 21 |
| DOIs | |
| Publication status | Published - Nov 19 2002 |
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Keywords
- Aorta
- Atherosclerosis
- Coronary disease
- Infection
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine
Cite this
Lack of association between serum immunoreactivity and Chlamydia pneumoniae detection in the human aortic wall. / Porqueddu, Massimo; Spirito, Rita; Parolari, Alessandro; Zanobini, Marco; Pompilio, Giulio; Polvani, Gianluca; Alamanni, Francesco; Stangalini, Davide; Tremoli, Elena; Biglioli, Paolo.
In: Circulation, Vol. 106, No. 21, 19.11.2002, p. 2647-2648.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lack of association between serum immunoreactivity and Chlamydia pneumoniae detection in the human aortic wall
AU - Porqueddu, Massimo
AU - Spirito, Rita
AU - Parolari, Alessandro
AU - Zanobini, Marco
AU - Pompilio, Giulio
AU - Polvani, Gianluca
AU - Alamanni, Francesco
AU - Stangalini, Davide
AU - Tremoli, Elena
AU - Biglioli, Paolo
PY - 2002/11/19
Y1 - 2002/11/19
N2 - Background - Only a few studies have focused the attention on the relation between elevated anti-Chlamydia pneumoniae (CP) antibodies and the detection of CP in the arterial wall. The aim of our study is thus to investigate the relationship between immune response to CP and detection of CP in the aortic walls of patients with abdominal aortic aneurysm. Methods and Results - A specimen of aortic wall was obtained from 102 consecutive patients who underwent abdominal aneurysm repair. The possible presence of CP was studied by polymerase chain reaction and confirmed by nonradioactive DNA hybridization. Antibody response to CP was studied (IgG, IgA titers). We found 33 patients (32.4%) with CP DNA+. No correlation between CP DNA detection and antibody titers was found (IgG P=0.52, IgA P=0.66). High correlation between IgG and IgA titer was observed (P
AB - Background - Only a few studies have focused the attention on the relation between elevated anti-Chlamydia pneumoniae (CP) antibodies and the detection of CP in the arterial wall. The aim of our study is thus to investigate the relationship between immune response to CP and detection of CP in the aortic walls of patients with abdominal aortic aneurysm. Methods and Results - A specimen of aortic wall was obtained from 102 consecutive patients who underwent abdominal aneurysm repair. The possible presence of CP was studied by polymerase chain reaction and confirmed by nonradioactive DNA hybridization. Antibody response to CP was studied (IgG, IgA titers). We found 33 patients (32.4%) with CP DNA+. No correlation between CP DNA detection and antibody titers was found (IgG P=0.52, IgA P=0.66). High correlation between IgG and IgA titer was observed (P
KW - Aorta
KW - Atherosclerosis
KW - Coronary disease
KW - Infection
UR - http://www.scopus.com/inward/record.url?scp=0037137304&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037137304&partnerID=8YFLogxK
U2 - 10.1161/01.CIR.0000041626.38101.DB
DO - 10.1161/01.CIR.0000041626.38101.DB
M3 - Article
C2 - 12438287
AN - SCOPUS:0037137304
VL - 106
SP - 2647
EP - 2648
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 21
ER -