Lack of association between serum immunoreactivity and Chlamydia pneumoniae detection in the human aortic wall

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Abstract

Background - Only a few studies have focused the attention on the relation between elevated anti-Chlamydia pneumoniae (CP) antibodies and the detection of CP in the arterial wall. The aim of our study is thus to investigate the relationship between immune response to CP and detection of CP in the aortic walls of patients with abdominal aortic aneurysm. Methods and Results - A specimen of aortic wall was obtained from 102 consecutive patients who underwent abdominal aneurysm repair. The possible presence of CP was studied by polymerase chain reaction and confirmed by nonradioactive DNA hybridization. Antibody response to CP was studied (IgG, IgA titers). We found 33 patients (32.4%) with CP DNA+. No correlation between CP DNA detection and antibody titers was found (IgG P=0.52, IgA P=0.66). High correlation between IgG and IgA titer was observed (P

Original languageEnglish
Pages (from-to)2647-2648
Number of pages2
JournalCirculation
Volume106
Issue number21
DOIs
Publication statusPublished - Nov 19 2002

Keywords

  • Aorta
  • Atherosclerosis
  • Coronary disease
  • Infection

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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