Lack of association between the CYP46 gene polymorphism and Italian late-onset sporadic Alzheimer's disease

Andrea Tedde, Mario Rotondi, Elena Cellini, Silvia Bagnoli, Laura Muratore, Benedetta Nacmias, Sandro Sorbi

Research output: Contribution to journalArticlepeer-review

Abstract

Recent studies have provided evidence toward the possible involvement of brain cholesterol homeostasis in late-onset Alzheimer's disease (LOAD). We analyzed an intronic T → C substitution (rs 754203) of the cholesterol 24S-hydroxylase (CYP46) gene, encoding an enzyme acting on brain cholesterol turnover, which has been recently associated with an increased risk of AD, dependent or not on Apolipoprotein E (ApoE) genotype. No significant association was found for the CYP46 polymorphism in LOAD compared to the controls, even after stratification for the presence/absence of the ApoE*4 allele. Our data do not support a role of the CYP46 polymorphism as a possible susceptibility factor for developing AD.

Original languageEnglish
JournalNeurobiology of Aging
Volume27
Issue number5
DOIs
Publication statusPublished - May 2006

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Cholesterol 24S-hydroxylase
  • Genetic factors
  • Polymorphism

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

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