Lack of Association between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies

Themistocles L. Assimes, Hilma Hlm, Sekar Kathiresan, Muredach P. Reilly, Gudmar Thorleifsson, Benjamin F. Voight, Jeanette Erdmann, Christina Willenborg, Dhananjay Vaidya, Changchun Xie, Chris C. Patterson, Thomas M. Morgan, Mary Susan Burnett, Mingyao Li, Mark A. Hlatky, Joshua W. Knowles, John R. Thompson, Devin Absher, Carlos Iribarren, Alan GoStephen P. Fortmann, Stephen Sidney, Neil Risch, Hua Tang, Richard M. Myers, Klaus Berger, Monika Stoll, Svati H. Shah, Gudmundur Thorgeirsson, Karl Andersen, Aki S. Havulinna, J. Enrique Herrera, Nauder Faraday, Yoonhee Kim, Brian G. Kral, Rasika A. Mathias, Ingo Ruczinski, Bhoom Suktitipat, Alexander F. Wilson, Lisa R. Yanek, Lewis C. Becker, Patrick Linsel-Nitschke, Wolfgang Lieb, Inke R. Knig, Christian Hengstenberg, Marcus Fischer, Klaus Stark, Wibke Reinhard, Janina Winogradow, Martina Grassl, Anika Grosshennig, Michael Preuss, Stefan Schreiber, H. Erich Wichmann, Christa Meisinger, Jean Yee, Yechiel Friedlander, Ron Do, James B. Meigs, Gordon Williams, David M. Nathan, Calum A. MacRae, Liming Qu, Robert L. Wilensky, William H. Matthai, Atif N. Qasim, Hakon Hakonarson, Augusto D. Pichard, Kenneth M. Kent, Lowell Satler, Joseph M. Lindsay, Ron Waksman, Christopher W. Knouff, Dawn M. Waterworth, Max C. Walker, Vincent E. Mooser, Jaume Marrugat, Gavin Lucas, Isaac Subirana, Joan Sala, Rafael Ramos, Nicola Martinelli, Oliviero Olivieri, Elisabetta Trabetti, Giovanni Malerba, Pier Franco Pignatti, Candace Guiducci, Daniel Mirel, Melissa Parkin, Joel N. Hirschhorn, Rosanna Asselta, Stefano Duga, Kiran Musunuru, Mark J. Daly, Shaun Purcell, Sandra Eifert, Peter S. Braund, Benjamin J. Wright, Anthony J. Balmforth, Stephen G. Ball, Willem H. Ouwehand, Panos Deloukas, Michael Scholz, Francois Cambien, Andreas Huge, Thomas Scheffold, Veikko Salomaa, Domenico Girelli, Christopher B. Granger, Leena Peltonen, Pascal P. McKeown, David Altshuler, Olle Melander, Joseph M. Devaney, Stephen E. Epstein, Daniel J. Rader, Roberto Elosua, James C. Engert, Sonia S. Anand, Alistair S. Hall, Andreas Ziegler, Christopher J. O'Donnell, John A. Spertus, David Siscovick, Stephen M. Schwartz, Diane Becker, Unnur Thorsteinsdottir, Kari Stefansson, Heribert Schunkert, Nilesh J. Samani, Thomas Quertermous

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Objectives We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD). Background Recent prospective studies suggest that carriers of the 719Arg allele in KIF6 are at increased risk of clinical CAD compared with noncarriers. Methods The KIF6 Trp719Arg polymorphism (rs20455) was genotyped in 19 case-control studies of nonfatal CAD either as part of a genome-wide association study or in a formal attempt to replicate the initial positive reports. Results A total of 17,000 cases and 39,369 controls of European descent as well as a modest number of South Asians, African Americans, Hispanics, East Asians, and admixed cases and controls were successfully genotyped. None of the 19 studies demonstrated an increased risk of CAD in carriers of the 719Arg allele compared with noncarriers. Regression analyses and fixed-effects meta-analyses ruled out with high degree of confidence an increase of

Original languageEnglish
Pages (from-to)1552-1563
Number of pages12
JournalJournal of the American College of Cardiology
Volume56
Issue number19
DOIs
Publication statusPublished - Nov 2 2010

Fingerprint

Kinesin
Case-Control Studies
Coronary Artery Disease
Proteins
Alleles
Asian Americans
Genome-Wide Association Study
Hispanic Americans
African Americans
Meta-Analysis
Regression Analysis
Prospective Studies

Keywords

  • Abbreviations and Acronyms
  • CAD
  • CI
  • confidence interval
  • coronary artery disease
  • hazard ratio
  • HR
  • MI
  • myocardial infarction
  • odds ratio
  • OR
  • single nucleotide polymorphism
  • SNP

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Lack of Association between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies. / Assimes, Themistocles L.; Hlm, Hilma; Kathiresan, Sekar; Reilly, Muredach P.; Thorleifsson, Gudmar; Voight, Benjamin F.; Erdmann, Jeanette; Willenborg, Christina; Vaidya, Dhananjay; Xie, Changchun; Patterson, Chris C.; Morgan, Thomas M.; Burnett, Mary Susan; Li, Mingyao; Hlatky, Mark A.; Knowles, Joshua W.; Thompson, John R.; Absher, Devin; Iribarren, Carlos; Go, Alan; Fortmann, Stephen P.; Sidney, Stephen; Risch, Neil; Tang, Hua; Myers, Richard M.; Berger, Klaus; Stoll, Monika; Shah, Svati H.; Thorgeirsson, Gudmundur; Andersen, Karl; Havulinna, Aki S.; Herrera, J. Enrique; Faraday, Nauder; Kim, Yoonhee; Kral, Brian G.; Mathias, Rasika A.; Ruczinski, Ingo; Suktitipat, Bhoom; Wilson, Alexander F.; Yanek, Lisa R.; Becker, Lewis C.; Linsel-Nitschke, Patrick; Lieb, Wolfgang; Knig, Inke R.; Hengstenberg, Christian; Fischer, Marcus; Stark, Klaus; Reinhard, Wibke; Winogradow, Janina; Grassl, Martina; Grosshennig, Anika; Preuss, Michael; Schreiber, Stefan; Wichmann, H. Erich; Meisinger, Christa; Yee, Jean; Friedlander, Yechiel; Do, Ron; Meigs, James B.; Williams, Gordon; Nathan, David M.; MacRae, Calum A.; Qu, Liming; Wilensky, Robert L.; Matthai, William H.; Qasim, Atif N.; Hakonarson, Hakon; Pichard, Augusto D.; Kent, Kenneth M.; Satler, Lowell; Lindsay, Joseph M.; Waksman, Ron; Knouff, Christopher W.; Waterworth, Dawn M.; Walker, Max C.; Mooser, Vincent E.; Marrugat, Jaume; Lucas, Gavin; Subirana, Isaac; Sala, Joan; Ramos, Rafael; Martinelli, Nicola; Olivieri, Oliviero; Trabetti, Elisabetta; Malerba, Giovanni; Pignatti, Pier Franco; Guiducci, Candace; Mirel, Daniel; Parkin, Melissa; Hirschhorn, Joel N.; Asselta, Rosanna; Duga, Stefano; Musunuru, Kiran; Daly, Mark J.; Purcell, Shaun; Eifert, Sandra; Braund, Peter S.; Wright, Benjamin J.; Balmforth, Anthony J.; Ball, Stephen G.; Ouwehand, Willem H.; Deloukas, Panos; Scholz, Michael; Cambien, Francois; Huge, Andreas; Scheffold, Thomas; Salomaa, Veikko; Girelli, Domenico; Granger, Christopher B.; Peltonen, Leena; McKeown, Pascal P.; Altshuler, David; Melander, Olle; Devaney, Joseph M.; Epstein, Stephen E.; Rader, Daniel J.; Elosua, Roberto; Engert, James C.; Anand, Sonia S.; Hall, Alistair S.; Ziegler, Andreas; O'Donnell, Christopher J.; Spertus, John A.; Siscovick, David; Schwartz, Stephen M.; Becker, Diane; Thorsteinsdottir, Unnur; Stefansson, Kari; Schunkert, Heribert; Samani, Nilesh J.; Quertermous, Thomas.

In: Journal of the American College of Cardiology, Vol. 56, No. 19, 02.11.2010, p. 1552-1563.

Research output: Contribution to journalArticle

Assimes, TL, Hlm, H, Kathiresan, S, Reilly, MP, Thorleifsson, G, Voight, BF, Erdmann, J, Willenborg, C, Vaidya, D, Xie, C, Patterson, CC, Morgan, TM, Burnett, MS, Li, M, Hlatky, MA, Knowles, JW, Thompson, JR, Absher, D, Iribarren, C, Go, A, Fortmann, SP, Sidney, S, Risch, N, Tang, H, Myers, RM, Berger, K, Stoll, M, Shah, SH, Thorgeirsson, G, Andersen, K, Havulinna, AS, Herrera, JE, Faraday, N, Kim, Y, Kral, BG, Mathias, RA, Ruczinski, I, Suktitipat, B, Wilson, AF, Yanek, LR, Becker, LC, Linsel-Nitschke, P, Lieb, W, Knig, IR, Hengstenberg, C, Fischer, M, Stark, K, Reinhard, W, Winogradow, J, Grassl, M, Grosshennig, A, Preuss, M, Schreiber, S, Wichmann, HE, Meisinger, C, Yee, J, Friedlander, Y, Do, R, Meigs, JB, Williams, G, Nathan, DM, MacRae, CA, Qu, L, Wilensky, RL, Matthai, WH, Qasim, AN, Hakonarson, H, Pichard, AD, Kent, KM, Satler, L, Lindsay, JM, Waksman, R, Knouff, CW, Waterworth, DM, Walker, MC, Mooser, VE, Marrugat, J, Lucas, G, Subirana, I, Sala, J, Ramos, R, Martinelli, N, Olivieri, O, Trabetti, E, Malerba, G, Pignatti, PF, Guiducci, C, Mirel, D, Parkin, M, Hirschhorn, JN, Asselta, R, Duga, S, Musunuru, K, Daly, MJ, Purcell, S, Eifert, S, Braund, PS, Wright, BJ, Balmforth, AJ, Ball, SG, Ouwehand, WH, Deloukas, P, Scholz, M, Cambien, F, Huge, A, Scheffold, T, Salomaa, V, Girelli, D, Granger, CB, Peltonen, L, McKeown, PP, Altshuler, D, Melander, O, Devaney, JM, Epstein, SE, Rader, DJ, Elosua, R, Engert, JC, Anand, SS, Hall, AS, Ziegler, A, O'Donnell, CJ, Spertus, JA, Siscovick, D, Schwartz, SM, Becker, D, Thorsteinsdottir, U, Stefansson, K, Schunkert, H, Samani, NJ & Quertermous, T 2010, 'Lack of Association between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies', Journal of the American College of Cardiology, vol. 56, no. 19, pp. 1552-1563. https://doi.org/10.1016/j.jacc.2010.06.022
Assimes, Themistocles L. ; Hlm, Hilma ; Kathiresan, Sekar ; Reilly, Muredach P. ; Thorleifsson, Gudmar ; Voight, Benjamin F. ; Erdmann, Jeanette ; Willenborg, Christina ; Vaidya, Dhananjay ; Xie, Changchun ; Patterson, Chris C. ; Morgan, Thomas M. ; Burnett, Mary Susan ; Li, Mingyao ; Hlatky, Mark A. ; Knowles, Joshua W. ; Thompson, John R. ; Absher, Devin ; Iribarren, Carlos ; Go, Alan ; Fortmann, Stephen P. ; Sidney, Stephen ; Risch, Neil ; Tang, Hua ; Myers, Richard M. ; Berger, Klaus ; Stoll, Monika ; Shah, Svati H. ; Thorgeirsson, Gudmundur ; Andersen, Karl ; Havulinna, Aki S. ; Herrera, J. Enrique ; Faraday, Nauder ; Kim, Yoonhee ; Kral, Brian G. ; Mathias, Rasika A. ; Ruczinski, Ingo ; Suktitipat, Bhoom ; Wilson, Alexander F. ; Yanek, Lisa R. ; Becker, Lewis C. ; Linsel-Nitschke, Patrick ; Lieb, Wolfgang ; Knig, Inke R. ; Hengstenberg, Christian ; Fischer, Marcus ; Stark, Klaus ; Reinhard, Wibke ; Winogradow, Janina ; Grassl, Martina ; Grosshennig, Anika ; Preuss, Michael ; Schreiber, Stefan ; Wichmann, H. Erich ; Meisinger, Christa ; Yee, Jean ; Friedlander, Yechiel ; Do, Ron ; Meigs, James B. ; Williams, Gordon ; Nathan, David M. ; MacRae, Calum A. ; Qu, Liming ; Wilensky, Robert L. ; Matthai, William H. ; Qasim, Atif N. ; Hakonarson, Hakon ; Pichard, Augusto D. ; Kent, Kenneth M. ; Satler, Lowell ; Lindsay, Joseph M. ; Waksman, Ron ; Knouff, Christopher W. ; Waterworth, Dawn M. ; Walker, Max C. ; Mooser, Vincent E. ; Marrugat, Jaume ; Lucas, Gavin ; Subirana, Isaac ; Sala, Joan ; Ramos, Rafael ; Martinelli, Nicola ; Olivieri, Oliviero ; Trabetti, Elisabetta ; Malerba, Giovanni ; Pignatti, Pier Franco ; Guiducci, Candace ; Mirel, Daniel ; Parkin, Melissa ; Hirschhorn, Joel N. ; Asselta, Rosanna ; Duga, Stefano ; Musunuru, Kiran ; Daly, Mark J. ; Purcell, Shaun ; Eifert, Sandra ; Braund, Peter S. ; Wright, Benjamin J. ; Balmforth, Anthony J. ; Ball, Stephen G. ; Ouwehand, Willem H. ; Deloukas, Panos ; Scholz, Michael ; Cambien, Francois ; Huge, Andreas ; Scheffold, Thomas ; Salomaa, Veikko ; Girelli, Domenico ; Granger, Christopher B. ; Peltonen, Leena ; McKeown, Pascal P. ; Altshuler, David ; Melander, Olle ; Devaney, Joseph M. ; Epstein, Stephen E. ; Rader, Daniel J. ; Elosua, Roberto ; Engert, James C. ; Anand, Sonia S. ; Hall, Alistair S. ; Ziegler, Andreas ; O'Donnell, Christopher J. ; Spertus, John A. ; Siscovick, David ; Schwartz, Stephen M. ; Becker, Diane ; Thorsteinsdottir, Unnur ; Stefansson, Kari ; Schunkert, Heribert ; Samani, Nilesh J. ; Quertermous, Thomas. / Lack of Association between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies. In: Journal of the American College of Cardiology. 2010 ; Vol. 56, No. 19. pp. 1552-1563.
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title = "Lack of Association between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies",
abstract = "Objectives We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD). Background Recent prospective studies suggest that carriers of the 719Arg allele in KIF6 are at increased risk of clinical CAD compared with noncarriers. Methods The KIF6 Trp719Arg polymorphism (rs20455) was genotyped in 19 case-control studies of nonfatal CAD either as part of a genome-wide association study or in a formal attempt to replicate the initial positive reports. Results A total of 17,000 cases and 39,369 controls of European descent as well as a modest number of South Asians, African Americans, Hispanics, East Asians, and admixed cases and controls were successfully genotyped. None of the 19 studies demonstrated an increased risk of CAD in carriers of the 719Arg allele compared with noncarriers. Regression analyses and fixed-effects meta-analyses ruled out with high degree of confidence an increase of",
keywords = "Abbreviations and Acronyms, CAD, CI, confidence interval, coronary artery disease, hazard ratio, HR, MI, myocardial infarction, odds ratio, OR, single nucleotide polymorphism, SNP",
author = "Assimes, {Themistocles L.} and Hilma Hlm and Sekar Kathiresan and Reilly, {Muredach P.} and Gudmar Thorleifsson and Voight, {Benjamin F.} and Jeanette Erdmann and Christina Willenborg and Dhananjay Vaidya and Changchun Xie and Patterson, {Chris C.} and Morgan, {Thomas M.} and Burnett, {Mary Susan} and Mingyao Li and Hlatky, {Mark A.} and Knowles, {Joshua W.} and Thompson, {John R.} and Devin Absher and Carlos Iribarren and Alan Go and Fortmann, {Stephen P.} and Stephen Sidney and Neil Risch and Hua Tang and Myers, {Richard M.} and Klaus Berger and Monika Stoll and Shah, {Svati H.} and Gudmundur Thorgeirsson and Karl Andersen and Havulinna, {Aki S.} and Herrera, {J. Enrique} and Nauder Faraday and Yoonhee Kim and Kral, {Brian G.} and Mathias, {Rasika A.} and Ingo Ruczinski and Bhoom Suktitipat and Wilson, {Alexander F.} and Yanek, {Lisa R.} and Becker, {Lewis C.} and Patrick Linsel-Nitschke and Wolfgang Lieb and Knig, {Inke R.} and Christian Hengstenberg and Marcus Fischer and Klaus Stark and Wibke Reinhard and Janina Winogradow and Martina Grassl and Anika Grosshennig and Michael Preuss and Stefan Schreiber and Wichmann, {H. Erich} and Christa Meisinger and Jean Yee and Yechiel Friedlander and Ron Do and Meigs, {James B.} and Gordon Williams and Nathan, {David M.} and MacRae, {Calum A.} and Liming Qu and Wilensky, {Robert L.} and Matthai, {William H.} and Qasim, {Atif N.} and Hakon Hakonarson and Pichard, {Augusto D.} and Kent, {Kenneth M.} and Lowell Satler and Lindsay, {Joseph M.} and Ron Waksman and Knouff, {Christopher W.} and Waterworth, {Dawn M.} and Walker, {Max C.} and Mooser, {Vincent E.} and Jaume Marrugat and Gavin Lucas and Isaac Subirana and Joan Sala and Rafael Ramos and Nicola Martinelli and Oliviero Olivieri and Elisabetta Trabetti and Giovanni Malerba and Pignatti, {Pier Franco} and Candace Guiducci and Daniel Mirel and Melissa Parkin and Hirschhorn, {Joel N.} and Rosanna Asselta and Stefano Duga and Kiran Musunuru and Daly, {Mark J.} and Shaun Purcell and Sandra Eifert and Braund, {Peter S.} and Wright, {Benjamin J.} and Balmforth, {Anthony J.} and Ball, {Stephen G.} and Ouwehand, {Willem H.} and Panos Deloukas and Michael Scholz and Francois Cambien and Andreas Huge and Thomas Scheffold and Veikko Salomaa and Domenico Girelli and Granger, {Christopher B.} and Leena Peltonen and McKeown, {Pascal P.} and David Altshuler and Olle Melander and Devaney, {Joseph M.} and Epstein, {Stephen E.} and Rader, {Daniel J.} and Roberto Elosua and Engert, {James C.} and Anand, {Sonia S.} and Hall, {Alistair S.} and Andreas Ziegler and O'Donnell, {Christopher J.} and Spertus, {John A.} and David Siscovick and Schwartz, {Stephen M.} and Diane Becker and Unnur Thorsteinsdottir and Kari Stefansson and Heribert Schunkert and Samani, {Nilesh J.} and Thomas Quertermous",
year = "2010",
month = "11",
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doi = "10.1016/j.jacc.2010.06.022",
language = "English",
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pages = "1552--1563",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
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TY - JOUR

T1 - Lack of Association between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies

AU - Assimes, Themistocles L.

AU - Hlm, Hilma

AU - Kathiresan, Sekar

AU - Reilly, Muredach P.

AU - Thorleifsson, Gudmar

AU - Voight, Benjamin F.

AU - Erdmann, Jeanette

AU - Willenborg, Christina

AU - Vaidya, Dhananjay

AU - Xie, Changchun

AU - Patterson, Chris C.

AU - Morgan, Thomas M.

AU - Burnett, Mary Susan

AU - Li, Mingyao

AU - Hlatky, Mark A.

AU - Knowles, Joshua W.

AU - Thompson, John R.

AU - Absher, Devin

AU - Iribarren, Carlos

AU - Go, Alan

AU - Fortmann, Stephen P.

AU - Sidney, Stephen

AU - Risch, Neil

AU - Tang, Hua

AU - Myers, Richard M.

AU - Berger, Klaus

AU - Stoll, Monika

AU - Shah, Svati H.

AU - Thorgeirsson, Gudmundur

AU - Andersen, Karl

AU - Havulinna, Aki S.

AU - Herrera, J. Enrique

AU - Faraday, Nauder

AU - Kim, Yoonhee

AU - Kral, Brian G.

AU - Mathias, Rasika A.

AU - Ruczinski, Ingo

AU - Suktitipat, Bhoom

AU - Wilson, Alexander F.

AU - Yanek, Lisa R.

AU - Becker, Lewis C.

AU - Linsel-Nitschke, Patrick

AU - Lieb, Wolfgang

AU - Knig, Inke R.

AU - Hengstenberg, Christian

AU - Fischer, Marcus

AU - Stark, Klaus

AU - Reinhard, Wibke

AU - Winogradow, Janina

AU - Grassl, Martina

AU - Grosshennig, Anika

AU - Preuss, Michael

AU - Schreiber, Stefan

AU - Wichmann, H. Erich

AU - Meisinger, Christa

AU - Yee, Jean

AU - Friedlander, Yechiel

AU - Do, Ron

AU - Meigs, James B.

AU - Williams, Gordon

AU - Nathan, David M.

AU - MacRae, Calum A.

AU - Qu, Liming

AU - Wilensky, Robert L.

AU - Matthai, William H.

AU - Qasim, Atif N.

AU - Hakonarson, Hakon

AU - Pichard, Augusto D.

AU - Kent, Kenneth M.

AU - Satler, Lowell

AU - Lindsay, Joseph M.

AU - Waksman, Ron

AU - Knouff, Christopher W.

AU - Waterworth, Dawn M.

AU - Walker, Max C.

AU - Mooser, Vincent E.

AU - Marrugat, Jaume

AU - Lucas, Gavin

AU - Subirana, Isaac

AU - Sala, Joan

AU - Ramos, Rafael

AU - Martinelli, Nicola

AU - Olivieri, Oliviero

AU - Trabetti, Elisabetta

AU - Malerba, Giovanni

AU - Pignatti, Pier Franco

AU - Guiducci, Candace

AU - Mirel, Daniel

AU - Parkin, Melissa

AU - Hirschhorn, Joel N.

AU - Asselta, Rosanna

AU - Duga, Stefano

AU - Musunuru, Kiran

AU - Daly, Mark J.

AU - Purcell, Shaun

AU - Eifert, Sandra

AU - Braund, Peter S.

AU - Wright, Benjamin J.

AU - Balmforth, Anthony J.

AU - Ball, Stephen G.

AU - Ouwehand, Willem H.

AU - Deloukas, Panos

AU - Scholz, Michael

AU - Cambien, Francois

AU - Huge, Andreas

AU - Scheffold, Thomas

AU - Salomaa, Veikko

AU - Girelli, Domenico

AU - Granger, Christopher B.

AU - Peltonen, Leena

AU - McKeown, Pascal P.

AU - Altshuler, David

AU - Melander, Olle

AU - Devaney, Joseph M.

AU - Epstein, Stephen E.

AU - Rader, Daniel J.

AU - Elosua, Roberto

AU - Engert, James C.

AU - Anand, Sonia S.

AU - Hall, Alistair S.

AU - Ziegler, Andreas

AU - O'Donnell, Christopher J.

AU - Spertus, John A.

AU - Siscovick, David

AU - Schwartz, Stephen M.

AU - Becker, Diane

AU - Thorsteinsdottir, Unnur

AU - Stefansson, Kari

AU - Schunkert, Heribert

AU - Samani, Nilesh J.

AU - Quertermous, Thomas

PY - 2010/11/2

Y1 - 2010/11/2

N2 - Objectives We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD). Background Recent prospective studies suggest that carriers of the 719Arg allele in KIF6 are at increased risk of clinical CAD compared with noncarriers. Methods The KIF6 Trp719Arg polymorphism (rs20455) was genotyped in 19 case-control studies of nonfatal CAD either as part of a genome-wide association study or in a formal attempt to replicate the initial positive reports. Results A total of 17,000 cases and 39,369 controls of European descent as well as a modest number of South Asians, African Americans, Hispanics, East Asians, and admixed cases and controls were successfully genotyped. None of the 19 studies demonstrated an increased risk of CAD in carriers of the 719Arg allele compared with noncarriers. Regression analyses and fixed-effects meta-analyses ruled out with high degree of confidence an increase of

AB - Objectives We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD). Background Recent prospective studies suggest that carriers of the 719Arg allele in KIF6 are at increased risk of clinical CAD compared with noncarriers. Methods The KIF6 Trp719Arg polymorphism (rs20455) was genotyped in 19 case-control studies of nonfatal CAD either as part of a genome-wide association study or in a formal attempt to replicate the initial positive reports. Results A total of 17,000 cases and 39,369 controls of European descent as well as a modest number of South Asians, African Americans, Hispanics, East Asians, and admixed cases and controls were successfully genotyped. None of the 19 studies demonstrated an increased risk of CAD in carriers of the 719Arg allele compared with noncarriers. Regression analyses and fixed-effects meta-analyses ruled out with high degree of confidence an increase of

KW - Abbreviations and Acronyms

KW - CAD

KW - CI

KW - confidence interval

KW - coronary artery disease

KW - hazard ratio

KW - HR

KW - MI

KW - myocardial infarction

KW - odds ratio

KW - OR

KW - single nucleotide polymorphism

KW - SNP

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UR - http://www.scopus.com/inward/citedby.url?scp=78049327781&partnerID=8YFLogxK

U2 - 10.1016/j.jacc.2010.06.022

DO - 10.1016/j.jacc.2010.06.022

M3 - Article

C2 - 20933357

AN - SCOPUS:78049327781

VL - 56

SP - 1552

EP - 1563

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 19

ER -