TY - JOUR
T1 - Lack of association for reported endocrine pancreatic cancer risk Loci in the PANDoRA consortium
AU - Campa, Daniele
AU - Obazee, Ofure
AU - Pastore, Manuela
AU - Panzuto, Francesco
AU - Liço, Valbona
AU - Greenhalf, William
AU - Katzke, Verena
AU - Tavano, Francesca
AU - Costello, Eithne
AU - Corbo, Vincenzo
AU - Talar-Wojnarowska, Renata
AU - Strobel, Oliver
AU - Zambon, Carlo Federico
AU - Neoptolemos, John P.
AU - Zerboni, Giulia
AU - Kaaks, Rudolf
AU - Key, Timothy J.
AU - Lombardo, Carlo
AU - Jamroziak, Krzysztof
AU - Gioffreda, Domenica
AU - Hackert, Thilo
AU - Khaw, Kay Tee
AU - Landi, Stefano
AU - Milanetto, Anna Caterina
AU - Landoni, Luca
AU - Lawlor, Rita T.
AU - Bambi, Franco
AU - Pirozzi, Felice
AU - Basso, Daniela
AU - Pasquali, Claudio
AU - Capurso, Gabriele
AU - Canzian, Federico
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Background: Pancreatic neuroendocrine tumors (PNETs) are rare neoplasms for which very little is known about either environmental or genetic risk factors. Only a handful of association studies have been performed so far, suggesting a small number of risk loci. Methods: To replicate the best findings, we have selected 16 SNPs suggested in previous studies to be relevant in PNET etiogenesis. We genotyped the selected SNPs (rs16944, rs1052536, rs1059293, rs1136410, rs1143634, rs2069762, rs2236302, rs2387632, rs3212961, rs3734299, rs3803258, rs4962081, rs7234941, rs7243091, rs12957119, and rs1800629) in 344 PNET sporadic cases and 2, 721 controls in the context of the PANcreatic Disease ReseArch (PANDoRA) consortium. Results: After correction for multiple testing, we did not observe any statistically significant association between the SNPs and PNET risk. We also used three online bioinformatic tools (HaploReg, RegulomeDB, and GTEx) to predict a possible functional role of the SNPs, but we did not observe any clear indication. Conclusions: None of the selected SNPs were convincingly associated with PNET risk in the PANDoRA consortium. Impact:Wecan exclude a major role of the selected polymorphisms in PNET etiology, and this highlights the need for replication of epidemiologic findings in independent populations, especially in rare diseases such as PNETs. Cancer Epidemiol Biomarkers Prev; 26(8); 1349-51.
AB - Background: Pancreatic neuroendocrine tumors (PNETs) are rare neoplasms for which very little is known about either environmental or genetic risk factors. Only a handful of association studies have been performed so far, suggesting a small number of risk loci. Methods: To replicate the best findings, we have selected 16 SNPs suggested in previous studies to be relevant in PNET etiogenesis. We genotyped the selected SNPs (rs16944, rs1052536, rs1059293, rs1136410, rs1143634, rs2069762, rs2236302, rs2387632, rs3212961, rs3734299, rs3803258, rs4962081, rs7234941, rs7243091, rs12957119, and rs1800629) in 344 PNET sporadic cases and 2, 721 controls in the context of the PANcreatic Disease ReseArch (PANDoRA) consortium. Results: After correction for multiple testing, we did not observe any statistically significant association between the SNPs and PNET risk. We also used three online bioinformatic tools (HaploReg, RegulomeDB, and GTEx) to predict a possible functional role of the SNPs, but we did not observe any clear indication. Conclusions: None of the selected SNPs were convincingly associated with PNET risk in the PANDoRA consortium. Impact:Wecan exclude a major role of the selected polymorphisms in PNET etiology, and this highlights the need for replication of epidemiologic findings in independent populations, especially in rare diseases such as PNETs. Cancer Epidemiol Biomarkers Prev; 26(8); 1349-51.
UR - http://www.scopus.com/inward/record.url?scp=85026845386&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85026845386&partnerID=8YFLogxK
U2 - 10.1158/1055-9965.EPI-17-0075
DO - 10.1158/1055-9965.EPI-17-0075
M3 - Article
AN - SCOPUS:85026845386
VL - 26
SP - 1349
EP - 1351
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
SN - 1055-9965
IS - 8
ER -