Lack of association of PON polymorphisms with sporadic ALS in an Italian population

Claudia Ricci, Stefania Battistini, Lorena Cozzi, Michele Benigni, Paola Origone, Lorenzo Verriello, Christian Lunetta, Cristina Cereda, Pamela Milani, Giuseppe Greco, Maria Cristina Patrosso, Renzo Causarano, Claudia Caponnetto, Fabio Giannini, Massimo Corbo, Silvana Penco

Research output: Contribution to journalArticlepeer-review

Abstract

Paraoxonase (PON) gene polymorphisms have been associated with susceptibility to sporadic amyotrophic lateral sclerosis (ALS). We have investigated the role of the previously associated single nucleotide polymorphisms rs854560, rs662, and rs6954345 in 350 ALS patients and 376 matched controls from Italy. No significant association was observed at genotype and haplotype level. Our data suggest that PON polymorphisms are not involved in ALS pathogenesis in an Italian population.

Original languageEnglish
JournalNeurobiology of Aging
Volume32
Issue number3
DOIs
Publication statusPublished - Mar 2011

Keywords

  • Amyotrophic lateral sclerosis
  • Paraoxonase (PON) genes
  • Single nucleotide polymorphisms

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Geriatrics and Gerontology

Fingerprint Dive into the research topics of 'Lack of association of PON polymorphisms with sporadic ALS in an Italian population'. Together they form a unique fingerprint.

Cite this