Lack of association of the dopamine transporter gene in a French ADHD sample

M. Wohl, C. Boni, M. Asch, S. Cortese, S. Orejarena, M. C. Mouren, P. Gorwood, D. Purper-Ouaki

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Discrepancies in the role of the 40 bp VNTR polymorphism of the dopamine transporter gene (DAT1) in attention-deficit hyperactivity disorder (ADHD) could be due to various sources of genetic or phenotypical heterogeneity. We therefore analyzed a sample of 146 ADHD children and their parents, with a transmission disequilibrium test (TDT) design, assessing age, inattention, and hyperactivity dimensions and total score of the ADHD Rating Scale, the number of errors and the total score at Stroop Color-Word test, and the total score at the Trail Making Test. The TDT for 10-repeat (10-R) allele shows a perfect lack of transmission bias (Mc Nemar χ2 = 0) and PBAT analyses showed no role of this polymorphism for any of the studied endophenotypes. Lack of statistical power is always a possibility, but with a sample size above the average of the majority of previous studies, and an odds ratio (number of transmitted versus untransmitted 10-R allele) of 1.00 exactly, this possibility may be considered as not very likely.

Original languageEnglish
Pages (from-to)1509-1510
Number of pages2
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume147
Issue number8
DOIs
Publication statusPublished - Dec 5 2008

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Dopamine Plasma Membrane Transport Proteins
Attention Deficit Disorder with Hyperactivity
Alleles
Trail Making Test
Genes
Endophenotypes
Sample Size
Color
Parents
Odds Ratio

Keywords

  • Association
  • DAT
  • TDT

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Wohl, M., Boni, C., Asch, M., Cortese, S., Orejarena, S., Mouren, M. C., ... Purper-Ouaki, D. (2008). Lack of association of the dopamine transporter gene in a French ADHD sample. American Journal of Medical Genetics - Neuropsychiatric Genetics, 147(8), 1509-1510. https://doi.org/10.1002/ajmg.b.30695

Lack of association of the dopamine transporter gene in a French ADHD sample. / Wohl, M.; Boni, C.; Asch, M.; Cortese, S.; Orejarena, S.; Mouren, M. C.; Gorwood, P.; Purper-Ouaki, D.

In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 147, No. 8, 05.12.2008, p. 1509-1510.

Research output: Contribution to journalArticle

Wohl, M, Boni, C, Asch, M, Cortese, S, Orejarena, S, Mouren, MC, Gorwood, P & Purper-Ouaki, D 2008, 'Lack of association of the dopamine transporter gene in a French ADHD sample', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 147, no. 8, pp. 1509-1510. https://doi.org/10.1002/ajmg.b.30695
Wohl, M. ; Boni, C. ; Asch, M. ; Cortese, S. ; Orejarena, S. ; Mouren, M. C. ; Gorwood, P. ; Purper-Ouaki, D. / Lack of association of the dopamine transporter gene in a French ADHD sample. In: American Journal of Medical Genetics - Neuropsychiatric Genetics. 2008 ; Vol. 147, No. 8. pp. 1509-1510.
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