Lack of association of the dopamine transporter gene in a French ADHD sample

M. Wohl, C. Boni, M. Asch, S. Cortese, S. Orejarena, M. C. Mouren, P. Gorwood, D. Purper-Ouaki

Research output: Contribution to journalArticlepeer-review

Abstract

Discrepancies in the role of the 40 bp VNTR polymorphism of the dopamine transporter gene (DAT1) in attention-deficit hyperactivity disorder (ADHD) could be due to various sources of genetic or phenotypical heterogeneity. We therefore analyzed a sample of 146 ADHD children and their parents, with a transmission disequilibrium test (TDT) design, assessing age, inattention, and hyperactivity dimensions and total score of the ADHD Rating Scale, the number of errors and the total score at Stroop Color-Word test, and the total score at the Trail Making Test. The TDT for 10-repeat (10-R) allele shows a perfect lack of transmission bias (Mc Nemar χ2 = 0) and PBAT analyses showed no role of this polymorphism for any of the studied endophenotypes. Lack of statistical power is always a possibility, but with a sample size above the average of the majority of previous studies, and an odds ratio (number of transmitted versus untransmitted 10-R allele) of 1.00 exactly, this possibility may be considered as not very likely.

Original languageEnglish
Pages (from-to)1509-1510
Number of pages2
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume147
Issue number8
DOIs
Publication statusPublished - Dec 5 2008

Keywords

  • Association
  • DAT
  • TDT

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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