Lack of both spinal fluid oligoclonal bands and complement 4A protein in an MS patient

D. Franciotta, G. Piccolo, M. Cuccia, R. Bergamaschi, E. Zardini, G. V. Melzi d'Eril, E. Dondi, V. Cosi

Research output: Contribution to journalArticlepeer-review

Abstract

We report the case of a multiple sclerosis (MS) patient without oligoclonal bands (OCB) in three cerebrospinal fluid samples. Restriction fragment length polymorphism analysis of Class 3 genes with radiolabelled specific cDNA probes showed a homozygous deletion of the complement 4A (C4A) genes. Consequent lack of C4A protein can alter the development of humoral immune response probably preventing OCB production. Our observation may suggest a link between a rare immunogenetic pattern and the absence of OCB in MS.

Original languageEnglish
Pages (from-to)72-74
Number of pages3
JournalActa Neurologica Scandinavica
Volume89
Issue number1
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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