TY - JOUR
T1 - Lack of CD27- CD45RA -V γ9V δ2+ t cell effectors in immunocompromised hosts and during active pulmonary tuberculosis
AU - Gioia, Cristiana
AU - Agrati, Chiara
AU - Casetti, Rita
AU - Cairo, Cristiana
AU - Borsellino, Giovanna
AU - Battistini, Luca
AU - Mancino, Giorgio
AU - Goletti, Delia
AU - Colizzi, Vittorio
AU - Pucillo, Leopoldo P.
AU - Poccia, Fabrizio
PY - 2002/2/1
Y1 - 2002/2/1
N2 - In humans, the circulating pool of mycobacteria-reactive V γ9V δ2+ T cells is expanded with age and may contribute to Mycobacterium tuberculosis immunosurveillance. We observed that two subsets of V γ9V δ2+ T cells could be identified on the basis of CD27 expression in immunocompetent adults, showing that functionally differentiated γδ T cells have lost CD27 expression. In contrast, the CD27-CD45RA -V γ9V δ2+ T cell subset of effector cells was absent in cord blood cells from healthy newborns and lacking in the peripheral blood from HIV-infected patients. Moreover, circulating V γ9V δ2+ T cell effectors were significantly reduced in patients with acute pulmonary tuberculosis, resulting in a reduced frequency of IFN-γ-producing cells after stimulation with nonpeptidic mycobacterial ligands. These observations indicate that monitoring and boosting γδ T cell effectors could be clinically relevant both in immunocompromised hosts and during active tuberculosis disease.
AB - In humans, the circulating pool of mycobacteria-reactive V γ9V δ2+ T cells is expanded with age and may contribute to Mycobacterium tuberculosis immunosurveillance. We observed that two subsets of V γ9V δ2+ T cells could be identified on the basis of CD27 expression in immunocompetent adults, showing that functionally differentiated γδ T cells have lost CD27 expression. In contrast, the CD27-CD45RA -V γ9V δ2+ T cell subset of effector cells was absent in cord blood cells from healthy newborns and lacking in the peripheral blood from HIV-infected patients. Moreover, circulating V γ9V δ2+ T cell effectors were significantly reduced in patients with acute pulmonary tuberculosis, resulting in a reduced frequency of IFN-γ-producing cells after stimulation with nonpeptidic mycobacterial ligands. These observations indicate that monitoring and boosting γδ T cell effectors could be clinically relevant both in immunocompromised hosts and during active tuberculosis disease.
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M3 - Article
C2 - 11801693
AN - SCOPUS:0036467422
VL - 168
SP - 1484
EP - 1489
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 3
ER -