Lack of CD27- CD45RA -V γ9V δ2+ t cell effectors in immunocompromised hosts and during active pulmonary tuberculosis

Cristiana Gioia, Chiara Agrati, Rita Casetti, Cristiana Cairo, Giovanna Borsellino, Luca Battistini, Giorgio Mancino, Delia Goletti, Vittorio Colizzi, Leopoldo P. Pucillo, Fabrizio Poccia

Research output: Contribution to journalArticle

Abstract

In humans, the circulating pool of mycobacteria-reactive V γ9V δ2+ T cells is expanded with age and may contribute to Mycobacterium tuberculosis immunosurveillance. We observed that two subsets of V γ9V δ2+ T cells could be identified on the basis of CD27 expression in immunocompetent adults, showing that functionally differentiated γδ T cells have lost CD27 expression. In contrast, the CD27-CD45RA -V γ9V δ2+ T cell subset of effector cells was absent in cord blood cells from healthy newborns and lacking in the peripheral blood from HIV-infected patients. Moreover, circulating V γ9V δ2+ T cell effectors were significantly reduced in patients with acute pulmonary tuberculosis, resulting in a reduced frequency of IFN-γ-producing cells after stimulation with nonpeptidic mycobacterial ligands. These observations indicate that monitoring and boosting γδ T cell effectors could be clinically relevant both in immunocompromised hosts and during active tuberculosis disease.

Original languageEnglish
Pages (from-to)1484-1489
Number of pages6
JournalJournal of Immunology
Volume168
Issue number3
Publication statusPublished - Feb 1 2002

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ASJC Scopus subject areas

  • Immunology

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