Lack of chromosomal aberration and micronucleus induction in human lymphocytes exposed to pulsed magnetic fields

M. R. Scarfì, M. B. Lioi, O. Zeni, G. Franceschetti, C. Franceschi, F. Bersani

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Abstract

We expose human peripheral blood lymphocytes cultures to 50 Hz pulsed magnetic fields (PMFs) in order to evaluate a possible genotoxic effect of such non-ionizing radiation. The genotoxic effect was evaluated in terms of both micronucleus (MN) induction and classical chromosomal aberration (CA); the mitotic index (MI) was also calculated. Khalil and Qassem (1991)_found chromosomal and chromatid breaks and mitotic delay in human lymphocytes exposed for 24, 48 and 72 h to a field with characteristics similar to those used in our laboratory. These data are in contrast with our results previously reported in terms of MN induction using the cytokinesis block method (Scarfi et al., 1991). In this study lymphocytes from five healthy human donors were examined with the above mentioned tests. No genotoxic effects and increased MI were found in exposed samples compared to the control ones, in agreement with our previous results.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume306
Issue number2
DOIs
Publication statusPublished - Apr 15 1994

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Keywords

  • Chromosomal aberrations
  • Human lymphocytes
  • Micronuclei
  • Mitotic index
  • Pulsed magnetic field

ASJC Scopus subject areas

  • Molecular Biology
  • Health, Toxicology and Mutagenesis

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