Lack of correlation between the capability of inducing sister-chromatid exchanges in vivo and carcinogenic potency, for 16 aromatic amines and azo derivatives

Silvio Parodi, Annalisa Zunino, Laura Ottaggio, Marcella De Ferrari, Leonardo Santi

Research output: Contribution to journalArticlepeer-review

Abstract

16 aromatic amines and azo derivatives were studied. They were: benzidine; 2-acetylaminofluorene; 3′-methyl-p-dimethylaminoazobenzene; o-aminoazotoluene; p-dimethylaminoazobenzene; 2,4-diaminotoluene; 4,4′-oxydianiline; 2,4-diaminoanisole; 4,4′-methylenedianiline; 2-naphthylamine; auramine O; rhodamine B; ponceau MX; 1-naphthylamine; p-aminoazobenzene and aniline. Carcinogenic potency and potency in inducing sister-chromatid exchanges (SCEs) in vivo were compared. SCEs were absolutely not correlated with carcinogenic potency. A lack of correlation was also found with mutagenicity in the Ames test. On the contrary, a statistically significant correlation existed between DNA damage and SCEs.

Original languageEnglish
Pages (from-to)225-238
Number of pages14
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume108
Issue number1-3
DOIs
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Molecular Biology
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

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