Lack of correlation between the neurochemical and behavioural effects induced by d-amphetamine in chronically lead-treated rats

M. Memo, L. Lucchi, P. F. Spano, M. Trabucchi

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of injection of d-amphetamine in rats chronically treated with lead were studied using behavioural and neurochemical parameters. The locomotor activity of the lead-treated animals did not increase after d-amphetamine injection as it did in control animals. On the other hand, the biochemical changes induced by d-amphetamine in the central dopaminergic system were identical in the lead-treated rats and control animals. These results indicate lack of correlation between motor activity elicited by d-amphetamine and dopaminergic function in rats after chronic ingestion of lead.

Original languageEnglish
Pages (from-to)795-799
Number of pages5
JournalNeuropharmacology
Volume19
Issue number8
DOIs
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

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