The effects of injection of d-amphetamine in rats chronically treated with lead were studied using behavioural and neurochemical parameters. The locomotor activity of the lead-treated animals did not increase after d-amphetamine injection as it did in control animals. On the other hand, the biochemical changes induced by d-amphetamine in the central dopaminergic system were identical in the lead-treated rats and control animals. These results indicate lack of correlation between motor activity elicited by d-amphetamine and dopaminergic function in rats after chronic ingestion of lead.
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Drug Discovery