Lack of correlation between the neurochemical and behavioural effects induced by d-amphetamine in chronically lead-treated rats

M. Memo; L. Lucchi; P. F. Spano; M. Trabucchi

doi:10.1016/0028-3908(80)90073-8

Lack of correlation between the neurochemical and behavioural effects induced by d-amphetamine in chronically lead-treated rats

M. Memo, L. Lucchi, P. F. Spano, M. Trabucchi

Istituto di Neuroriabilitazione Motoria San Camillo

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of injection of d-amphetamine in rats chronically treated with lead were studied using behavioural and neurochemical parameters. The locomotor activity of the lead-treated animals did not increase after d-amphetamine injection as it did in control animals. On the other hand, the biochemical changes induced by d-amphetamine in the central dopaminergic system were identical in the lead-treated rats and control animals. These results indicate lack of correlation between motor activity elicited by d-amphetamine and dopaminergic function in rats after chronic ingestion of lead.

Original language	English
Pages (from-to)	795-799
Number of pages	5
Journal	Neuropharmacology
Volume	19
Issue number	8
DOIs	https://doi.org/10.1016/0028-3908(80)90073-8
Publication status	Published - 1980

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Drug Discovery
Pharmacology

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abstract = "The effects of injection of d-amphetamine in rats chronically treated with lead were studied using behavioural and neurochemical parameters. The locomotor activity of the lead-treated animals did not increase after d-amphetamine injection as it did in control animals. On the other hand, the biochemical changes induced by d-amphetamine in the central dopaminergic system were identical in the lead-treated rats and control animals. These results indicate lack of correlation between motor activity elicited by d-amphetamine and dopaminergic function in rats after chronic ingestion of lead.",

author = "M. Memo and L. Lucchi and Spano, {P. F.} and M. Trabucchi",

year = "1980",

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AU - Spano, P. F.

AU - Trabucchi, M.

PY - 1980

Y1 - 1980

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AB - The effects of injection of d-amphetamine in rats chronically treated with lead were studied using behavioural and neurochemical parameters. The locomotor activity of the lead-treated animals did not increase after d-amphetamine injection as it did in control animals. On the other hand, the biochemical changes induced by d-amphetamine in the central dopaminergic system were identical in the lead-treated rats and control animals. These results indicate lack of correlation between motor activity elicited by d-amphetamine and dopaminergic function in rats after chronic ingestion of lead.

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Lack of correlation between the neurochemical and behavioural effects induced by d-amphetamine in chronically lead-treated rats

Abstract

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