Abstract
The effects of injection of d-amphetamine in rats chronically treated with lead were studied using behavioural and neurochemical parameters. The locomotor activity of the lead-treated animals did not increase after d-amphetamine injection as it did in control animals. On the other hand, the biochemical changes induced by d-amphetamine in the central dopaminergic system were identical in the lead-treated rats and control animals. These results indicate lack of correlation between motor activity elicited by d-amphetamine and dopaminergic function in rats after chronic ingestion of lead.
| Original language | English |
|---|---|
| Pages (from-to) | 795-799 |
| Number of pages | 5 |
| Journal | Neuropharmacology |
| Volume | 19 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 1980 |
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ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Drug Discovery
- Pharmacology
Cite this
Lack of correlation between the neurochemical and behavioural effects induced by d-amphetamine in chronically lead-treated rats. / Memo, M.; Lucchi, L.; Spano, P. F.; Trabucchi, M.
In: Neuropharmacology, Vol. 19, No. 8, 1980, p. 795-799.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lack of correlation between the neurochemical and behavioural effects induced by d-amphetamine in chronically lead-treated rats
AU - Memo, M.
AU - Lucchi, L.
AU - Spano, P. F.
AU - Trabucchi, M.
PY - 1980
Y1 - 1980
N2 - The effects of injection of d-amphetamine in rats chronically treated with lead were studied using behavioural and neurochemical parameters. The locomotor activity of the lead-treated animals did not increase after d-amphetamine injection as it did in control animals. On the other hand, the biochemical changes induced by d-amphetamine in the central dopaminergic system were identical in the lead-treated rats and control animals. These results indicate lack of correlation between motor activity elicited by d-amphetamine and dopaminergic function in rats after chronic ingestion of lead.
AB - The effects of injection of d-amphetamine in rats chronically treated with lead were studied using behavioural and neurochemical parameters. The locomotor activity of the lead-treated animals did not increase after d-amphetamine injection as it did in control animals. On the other hand, the biochemical changes induced by d-amphetamine in the central dopaminergic system were identical in the lead-treated rats and control animals. These results indicate lack of correlation between motor activity elicited by d-amphetamine and dopaminergic function in rats after chronic ingestion of lead.
UR - http://www.scopus.com/inward/record.url?scp=0018933517&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018933517&partnerID=8YFLogxK
U2 - 10.1016/0028-3908(80)90073-8
DO - 10.1016/0028-3908(80)90073-8
M3 - Article
VL - 19
SP - 795
EP - 799
JO - Neuropharmacology
JF - Neuropharmacology
SN - 0028-3908
IS - 8
ER -