Abstract
The effects of injection of d-amphetamine in rats chronically treated with lead were studied using behavioural and neurochemical parameters. The locomotor activity of the lead-treated animals did not increase after d-amphetamine injection as it did in control animals. On the other hand, the biochemical changes induced by d-amphetamine in the central dopaminergic system were identical in the lead-treated rats and control animals. These results indicate lack of correlation between motor activity elicited by d-amphetamine and dopaminergic function in rats after chronic ingestion of lead.
Original language | English |
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Pages (from-to) | 795-799 |
Number of pages | 5 |
Journal | Neuropharmacology |
Volume | 19 |
Issue number | 8 |
DOIs | |
Publication status | Published - 1980 |
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Drug Discovery
- Pharmacology