TY - JOUR
T1 - Lack of correlation between TPA-induced prostaglandin biosynthesis and ornithine decarboxylase activity in BALB/c mouse 3T3 fibroblasts
AU - Tragni, Elena
AU - Corsini, Alberto
AU - Fumagalli, Remo
AU - Flaminio, Liliana
AU - Galli, Corrado L.
PY - 1986/8/29
Y1 - 1986/8/29
N2 - 12-0-tetradecanoylphorbol-13-acetate (TPA) induced in Balb/c 3T3 cells an earliest prostaglandin biosynthesis and an ornithine decarboxylase activation, this time-relation being more evident if serum was added to incubation medium in low concentration (0,2%). However the two TPA-induced events can be almost totally dissociated by pharmacological means, such as indomethacin and calcium-ionophore A23187 which affected PG response to TPA, but did not influence ODC induction.
AB - 12-0-tetradecanoylphorbol-13-acetate (TPA) induced in Balb/c 3T3 cells an earliest prostaglandin biosynthesis and an ornithine decarboxylase activation, this time-relation being more evident if serum was added to incubation medium in low concentration (0,2%). However the two TPA-induced events can be almost totally dissociated by pharmacological means, such as indomethacin and calcium-ionophore A23187 which affected PG response to TPA, but did not influence ODC induction.
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U2 - 10.1016/S0006-291X(86)80097-3
DO - 10.1016/S0006-291X(86)80097-3
M3 - Article
C2 - 3094508
AN - SCOPUS:0022455989
VL - 139
SP - 186
EP - 195
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -