12-0-tetradecanoylphorbol-13-acetate (TPA) induced in Balb/c 3T3 cells an earliest prostaglandin biosynthesis and an ornithine decarboxylase activation, this time-relation being more evident if serum was added to incubation medium in low concentration (0,2%). However the two TPA-induced events can be almost totally dissociated by pharmacological means, such as indomethacin and calcium-ionophore A23187 which affected PG response to TPA, but did not influence ODC induction.
|Number of pages||10|
|Journal||Biochemical and Biophysical Research Communications|
|Publication status||Published - Aug 29 1986|
ASJC Scopus subject areas
- Molecular Biology