Lack of correlation between TPA-induced prostaglandin biosynthesis and ornithine decarboxylase activity in BALB/c mouse 3T3 fibroblasts

Elena Tragni, Alberto Corsini, Remo Fumagalli, Liliana Flaminio, Corrado L. Galli

Research output: Contribution to journalArticlepeer-review

Abstract

12-0-tetradecanoylphorbol-13-acetate (TPA) induced in Balb/c 3T3 cells an earliest prostaglandin biosynthesis and an ornithine decarboxylase activation, this time-relation being more evident if serum was added to incubation medium in low concentration (0,2%). However the two TPA-induced events can be almost totally dissociated by pharmacological means, such as indomethacin and calcium-ionophore A23187 which affected PG response to TPA, but did not influence ODC induction.

Original languageEnglish
Pages (from-to)186-195
Number of pages10
JournalBiochemical and Biophysical Research Communications
Volume139
Issue number1
DOIs
Publication statusPublished - Aug 29 1986

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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