Lack of counteracting effect of liposomes on benserazide-induced hyperprolactinemia

G. Murialdo, P. Masturzo, A. Polleri, A. Carolei, G. Toffano

Research output: Contribution to journalArticle

Abstract

Benserazide induces an increase of serum prolactin in man, possibly as the result of an impairment of the dopamine effect on the pituitary and/or on the outer median eminence caused by the inhibition on L-dopa decarboxylase. On the other hand, liposomes obtained from bovine brain cortex phospholipids reduce serum prolactin possibly through an effect of phosphatidyl-serine on dopamine biosynthesis at the level of tyrosine hydroxylase. Benserazide, given orally (125 mg) to 5 normal subjects, induced an increase of serum prolactin that did not change when 300 mg of phospholipid liposomes were given intravenously 60 min later. An increase of L-dopa synthesis does not seem to be capable to overcome the effects of the decarboxylase inhibition.

Original languageEnglish
Pages (from-to)317-321
Number of pages5
JournalNeuropsychobiology
Volume5
Issue number6
DOIs
Publication statusPublished - 1979

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Keywords

  • Aromatic amino acids decarboxylase inhibitors
  • Liposomes
  • Phospholipids
  • Prolactin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychology(all)

Cite this

Murialdo, G., Masturzo, P., Polleri, A., Carolei, A., & Toffano, G. (1979). Lack of counteracting effect of liposomes on benserazide-induced hyperprolactinemia. Neuropsychobiology, 5(6), 317-321. https://doi.org/10.1159/000117697