Lack of effect of cholestyramine on phenytoin bioavailability

N. Barzaghi, M. Monteleone, C. Amione, S. Lecchini, E. Perucca, G. M. Frigo

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of cholestyramine (4 g qid for 5 days) on the kinetics of phenytoin (400 mg orally) was investigated in normal subjects. Apart from a trend toward faster phenytoin absorption, the serum level profile of the drug during concurrent cholestyramine coadministration was similar to that observed in a control session. Areas under the serum phenytoin concentration curves were virtually identical in the two occasions. It is concluded that cholestyramine does not significantly affect the bioavailability of a single dose of phenytoin.

Original languageEnglish
Pages (from-to)1112-1114
Number of pages3
JournalJournal of Clinical Pharmacology
Volume28
Issue number12
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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