Lack of effect of domperidone on gastrin release: evidence for a peripheral activity of the drug.

E. Masci, R. Caldara, PA Testoni, M. Guslandi, M. Cambielli, S. Passaretti, A. Tittobello

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of intravenous administration of domperidone, a dopamine receptor antagonist with peripheral activity, on basal and submaximal pentagastrin‐stimulated gastric acid secretion and gastrin release has been evaluated in healthy volunteers. No significant changes were observed in the parameters studied. The lack of effect on gastrin release appears to confirm that domperidone is unable to penetrate the blood brain barrier in appreciable amounts in adults. 1984 The British Pharmacological Society

Original languageEnglish
Pages (from-to)588-590
Number of pages3
JournalBritish Journal of Clinical Pharmacology
Volume17
Issue number5
DOIs
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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