TY - JOUR
T1 - Lack of effects of recombinant human growth hormone in a child with a complex cardiovascular malformation and dilated cardiomyopathy
AU - Rosti, Luca
AU - Cerini, E.
AU - Festa, P.
AU - Miola, A.
AU - Brunelli, V.
AU - Frigiola, A.
PY - 2000
Y1 - 2000
N2 - Recent studies have suggested the beneficial effects of GH treatment in patients with dilated cardiomyopathy. We have treated with recombinant human growth hormone (rhGH) a 6-year-old female with a complex congenital heart defect (severe tricuspid hypoplasia and malposition of the great arteries), who developed a progressive dilated cardiomyopathy of unknown etiology. rhGH treatment (0,1 U/kg/day, for 3 months) did not improve cardiac function, nor clinical symptoms, although we have no clear explanations for this. However, a trial with rhGH may be offered to children with dilated cardiomyopathy and waiting for heart transplantation. (C)2000, Editrice Kurtis.
AB - Recent studies have suggested the beneficial effects of GH treatment in patients with dilated cardiomyopathy. We have treated with recombinant human growth hormone (rhGH) a 6-year-old female with a complex congenital heart defect (severe tricuspid hypoplasia and malposition of the great arteries), who developed a progressive dilated cardiomyopathy of unknown etiology. rhGH treatment (0,1 U/kg/day, for 3 months) did not improve cardiac function, nor clinical symptoms, although we have no clear explanations for this. However, a trial with rhGH may be offered to children with dilated cardiomyopathy and waiting for heart transplantation. (C)2000, Editrice Kurtis.
KW - Congenital heart disease
KW - Dilated cardiomyopathy
KW - Growth hormone
KW - Heart failure
UR - http://www.scopus.com/inward/record.url?scp=0033983936&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033983936&partnerID=8YFLogxK
M3 - Article
C2 - 10698048
AN - SCOPUS:0033983936
VL - 23
SP - 28
EP - 30
JO - Journal of Endocrinological Investigation
JF - Journal of Endocrinological Investigation
SN - 0391-4097
IS - 1
ER -