Lack of endogenous opioid inhibitory tone on LH secretion in early puberty

F. Fraioli, M. Cappa, A. Fabbri, L. Gnessi, C. Moretti, P. Borrelli, A. Isidori

Research output: Contribution to journalArticlepeer-review

Abstract

Thirteen normal children, seven males and six females, during early puberty (I-II according to Tanner), have been studied. Each subject was injected at weekly intervals and in random order with 100 μg of LHRH, 0.2 mg/kg of naloxone and 0.9% of saline in single bolus. The gonadotrophin response was evaluated. The administration of naloxone failed to elevate LH levels in any of the subjects studied, even in those who showed a clear gonadotrophin response to LHRH. Unlike the response noted in adults, endogenous opiates do not appear to exert a tonic inhibitory influence on LH secretion during early puberty.

Original languageEnglish
Pages (from-to)299-305
Number of pages7
JournalClinical Endocrinology
Volume20
Issue number3
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Endocrinology

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