Lack of endogenous opioid inhibitory tone on LH secretion in early puberty

F. Fraioli; M. Cappa; A. Fabbri; L. Gnessi; C. Moretti; P. Borrelli; A. Isidori

Lack of endogenous opioid inhibitory tone on LH secretion in early puberty

F. Fraioli, M. Cappa, A. Fabbri, L. Gnessi, C. Moretti, P. Borrelli, A. Isidori

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Article › peer-review

Abstract

Thirteen normal children, seven males and six females, during early puberty (I-II according to Tanner), have been studied. Each subject was injected at weekly intervals and in random order with 100 μg of LHRH, 0.2 mg/kg of naloxone and 0.9% of saline in single bolus. The gonadotrophin response was evaluated. The administration of naloxone failed to elevate LH levels in any of the subjects studied, even in those who showed a clear gonadotrophin response to LHRH. Unlike the response noted in adults, endogenous opiates do not appear to exert a tonic inhibitory influence on LH secretion during early puberty.

Original language	English
Pages (from-to)	299-305
Number of pages	7
Journal	Clinical Endocrinology
Volume	20
Issue number	3
Publication status	Published - 1984

ASJC Scopus subject areas

Endocrinology

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title = "Lack of endogenous opioid inhibitory tone on LH secretion in early puberty",

abstract = "Thirteen normal children, seven males and six females, during early puberty (I-II according to Tanner), have been studied. Each subject was injected at weekly intervals and in random order with 100 μg of LHRH, 0.2 mg/kg of naloxone and 0.9% of saline in single bolus. The gonadotrophin response was evaluated. The administration of naloxone failed to elevate LH levels in any of the subjects studied, even in those who showed a clear gonadotrophin response to LHRH. Unlike the response noted in adults, endogenous opiates do not appear to exert a tonic inhibitory influence on LH secretion during early puberty.",

author = "F. Fraioli and M. Cappa and A. Fabbri and L. Gnessi and C. Moretti and P. Borrelli and A. Isidori",

year = "1984",

language = "English",

volume = "20",

pages = "299--305",

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issn = "0300-0664",

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T1 - Lack of endogenous opioid inhibitory tone on LH secretion in early puberty

AU - Fraioli, F.

AU - Cappa, M.

AU - Fabbri, A.

AU - Gnessi, L.

AU - Moretti, C.

AU - Borrelli, P.

AU - Isidori, A.

PY - 1984

Y1 - 1984

N2 - Thirteen normal children, seven males and six females, during early puberty (I-II according to Tanner), have been studied. Each subject was injected at weekly intervals and in random order with 100 μg of LHRH, 0.2 mg/kg of naloxone and 0.9% of saline in single bolus. The gonadotrophin response was evaluated. The administration of naloxone failed to elevate LH levels in any of the subjects studied, even in those who showed a clear gonadotrophin response to LHRH. Unlike the response noted in adults, endogenous opiates do not appear to exert a tonic inhibitory influence on LH secretion during early puberty.

AB - Thirteen normal children, seven males and six females, during early puberty (I-II according to Tanner), have been studied. Each subject was injected at weekly intervals and in random order with 100 μg of LHRH, 0.2 mg/kg of naloxone and 0.9% of saline in single bolus. The gonadotrophin response was evaluated. The administration of naloxone failed to elevate LH levels in any of the subjects studied, even in those who showed a clear gonadotrophin response to LHRH. Unlike the response noted in adults, endogenous opiates do not appear to exert a tonic inhibitory influence on LH secretion during early puberty.

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