Lack of evidence for an impairment of tuberoinfundibolar dopaminergic neurons in aged male rats of the sprague-dawley strain

S. Amoroso, G. F. Di Renzo, F. Maurano, P. Maida, M. Tagliatatela, L. Annunziato

Research output: Contribution to journalArticle

Abstract

Circulating prolactin (PRL) levels, dopamine (DA) content, in vitro basal and stimulus-evoked endogenous DA release from arcuate-periventricular nuclei median-eminence fragments were studied in young (4 months) and old (24-25 months) male rats of Sprague-Dawley strain. Serum PRL levels did not differ in young and aged animals. In addition DA tissue content, basal and K+- or d-amphetamine evoked endogenous DA release did not show age-related differences. These results suggest that in male rats of the Sprague-Dawley strain the activity of tuberoinfundibular dopaminergic (TIDA) neurons does not change during senescence, unlike what happens in other strains of rats.

Original languageEnglish
Pages (from-to)85-87
Number of pages3
JournalExperimental Aging Research
Volume13
Issue number2
DOIs
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Arts and Humanities (miscellaneous)
  • Ageing
  • Psychology(all)

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