TY - JOUR
T1 - Lack of evidence for an impairment of tuberoinfundibolar dopaminergic neurons in aged male rats of the sprague-dawley strain
AU - Amoroso, S.
AU - Di Renzo, G. F.
AU - Maurano, F.
AU - Maida, P.
AU - Tagliatatela, M.
AU - Annunziato, L.
PY - 1987
Y1 - 1987
N2 - Circulating prolactin (PRL) levels, dopamine (DA) content, in vitro basal and stimulus-evoked endogenous DA release from arcuate-periventricular nuclei median-eminence fragments were studied in young (4 months) and old (24-25 months) male rats of Sprague-Dawley strain. Serum PRL levels did not differ in young and aged animals. In addition DA tissue content, basal and K+- or d-amphetamine evoked endogenous DA release did not show age-related differences. These results suggest that in male rats of the Sprague-Dawley strain the activity of tuberoinfundibular dopaminergic (TIDA) neurons does not change during senescence, unlike what happens in other strains of rats.
AB - Circulating prolactin (PRL) levels, dopamine (DA) content, in vitro basal and stimulus-evoked endogenous DA release from arcuate-periventricular nuclei median-eminence fragments were studied in young (4 months) and old (24-25 months) male rats of Sprague-Dawley strain. Serum PRL levels did not differ in young and aged animals. In addition DA tissue content, basal and K+- or d-amphetamine evoked endogenous DA release did not show age-related differences. These results suggest that in male rats of the Sprague-Dawley strain the activity of tuberoinfundibular dopaminergic (TIDA) neurons does not change during senescence, unlike what happens in other strains of rats.
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U2 - 10.1080/03610738708259305
DO - 10.1080/03610738708259305
M3 - Article
C2 - 3678356
AN - SCOPUS:0023221361
VL - 13
SP - 85
EP - 87
JO - Experimental Aging Research
JF - Experimental Aging Research
SN - 0361-073X
IS - 2
ER -