Abstract
Circulating prolactin (PRL) levels, dopamine (DA) content, in vitro basal and stimulus-evoked endogenous DA release from arcuate-periventricular nuclei median-eminence fragments were studied in young (4 months) and old (24-25 months) male rats of Sprague-Dawley strain. Serum PRL levels did not differ in young and aged animals. In addition DA tissue content, basal and K+- or d-amphetamine evoked endogenous DA release did not show age-related differences. These results suggest that in male rats of the Sprague-Dawley strain the activity of tuberoinfundibular dopaminergic (TIDA) neurons does not change during senescence, unlike what happens in other strains of rats.
| Original language | English |
|---|---|
| Pages (from-to) | 85-87 |
| Number of pages | 3 |
| Journal | Experimental Aging Research |
| Volume | 13 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1987 |
ASJC Scopus subject areas
- Geriatrics and Gerontology
- Arts and Humanities (miscellaneous)
- Ageing
- Psychology(all)
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Amoroso, S., Di Renzo, G. F., Maurano, F., Maida, P., Tagliatatela, M., & Annunziato, L. (1987). Lack of evidence for an impairment of tuberoinfundibolar dopaminergic neurons in aged male rats of the sprague-dawley strain. Experimental Aging Research, 13(2), 85-87. https://doi.org/10.1080/03610738708259305