Lack of evidence for association between D2S124 and D2S111 polymorphisms of the SCN2A gene and idiopathic generalized epilepsy with generalized tonic-clonic seizures

Anna Volzone, Renata Rizzo, Antonella Gagliano, Mariella Palmarino, Paola Lucarelli, Carla Arpino, Paolo Curatolo

Research output: Contribution to journalArticlepeer-review

Abstract

Idiopathic generalized epilepsy syndromes are generally considered as brain channelopathies due to alteration of several genes. The aim of our study was to compare the distribution of D2S124 and D2S111 genetic polymorphisms of the SCN2A gene between cases with a specific idiopathic generalized epilepsy subtype (with generalized tonic-clonic seizures) and healthy controls. Allele frequencies of both the D2S111 and the D2S124 polymorphisms were not significantly different between cases and control. Further studies are needed to investigate if possible polymorphic variants of SCN2A gene may influence seizures susceptibility of idiopathic generalized epilepsy with tonic-clonic seizures.

Original languageEnglish
Pages (from-to)907-910
Number of pages4
JournalJournal of Child Neurology
Volume22
Issue number7
DOIs
Publication statusPublished - Jul 2007

Keywords

  • Genetic polymorphism
  • Idiopathic generalized epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

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