Lack of genetic association between the phospholipase A2 gene and bipolar mood disorder in a European multicentre case-control study

Dimitris G. Dikeos, George N. Papadimitriou, Daniel Souery, Jurgen Del-Favero, Isabelle Massat, Douglas Blackwood, Sven Cichon, Eugenia Daskalopoulou, Sladjana Ivezic, Radka Kaneva, Georgia Karadima, Cristina Lorenzi, Vihra Milanova, Walter Muir, Markus Nöthen, Lilijana Oruc, Marcella Rietschel, Alessandro Serretti, Christine Van Broeckhoven, Constantin R. SoldatosCostas N. Stefanis, Julien Mendlewicz

Research output: Contribution to journalArticle

Abstract

The possible association between phospholipase A2 gene and bipolar mood disorder was examined in 557 bipolar patients and 725 controls (all personally interviewed), recruited from seven countries (Belgium, Bulgaria, Croatia, Germany, Greece, Italy, and UK). The frequencies of the eight alleles that were identified did not differ between patients and control individuals in the whole population, while the power to detect an association based on our sample was relatively high. Some differences were noted among the various ethnic groups, but no significant trends existed, suggesting that population stratification by country may not be responsible for a type II error. On the basis of these results, mutations of the phospholipase A2 gene, at least in the region close to the polymorphism examined between exons 1 and 2, are not involved in the pathogenesis of bipolar mood disorder.

Original languageEnglish
Pages (from-to)169-171
Number of pages3
JournalPsychiatric Genetics
Volume16
Issue number4
DOIs
Publication statusPublished - Aug 2006

Keywords

  • Bipolar mood disorder
  • Chromosome 12
  • Genetic association
  • Phospholipase A2 gene
  • PLA2

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Genetics
  • Neuroscience(all)

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  • Cite this

    Dikeos, D. G., Papadimitriou, G. N., Souery, D., Del-Favero, J., Massat, I., Blackwood, D., Cichon, S., Daskalopoulou, E., Ivezic, S., Kaneva, R., Karadima, G., Lorenzi, C., Milanova, V., Muir, W., Nöthen, M., Oruc, L., Rietschel, M., Serretti, A., Van Broeckhoven, C., ... Mendlewicz, J. (2006). Lack of genetic association between the phospholipase A2 gene and bipolar mood disorder in a European multicentre case-control study. Psychiatric Genetics, 16(4), 169-171. https://doi.org/10.1097/01.ypg.0000218615.19892.86