Lack of genotoxic effect in workers exposed to very low doses of 1,3-butadiene

Piero Lovreglio, Nenad Bukvic, Silvia Fustinoni, Andrea Ballini, Ignazio Drago, Vito Foà, Ginevra Guanti, Leonardo Soleo

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

1,3-butadiene (BD), a probable carcinogen to humans, has been shown to have an ill-defined genotoxicity in occupationally exposed workers. In the present study, the influence of exposure to very low doses of BD and to cigarette smoking was investigated on some cytogenetic endpoints, namely, sister chromatid exchanges (SCE), chromosomal aberrations (CA) and cells with a high frequency of SCE (HFC), in peripheral blood lymphocytes. Twenty-seven male workers employed in a petrochemical plant and 26 matched controls were included in the study. As regards the airborne BD values, there was a significant difference between exposed (median BD value 1.5, min-max 0.2-69.0 μg/m3) and non-exposed workers (median BD value 0.4, min-max <0.1-3.8 μg/m 3). Genotoxic biomarkers were not able to distinguish between the two groups. The frequency of SCE was higher in smokers than in non-smokers (p = 0.001), with a positive correlation between the number of cigarettes smoked per day and both SCE (r = 0.4; p = 0.004) and HFC frequency (r = 0.3; p = 0.04). Multiple regression analysis confirmed the influence of cigarette smoking on the level of SCE and HFC, while these parameters were not affected by personal exposure to BD. Overall, the biomarkers of genotoxic effect investigated in our study were not able to discriminate between workers with a very low exposure to BD and controls, while it was possible to distinguish between smokers and non-smokers on the basis of SCE.

Original languageEnglish
Pages (from-to)378-381
Number of pages4
JournalArchives of Toxicology
Volume80
Issue number6
DOIs
Publication statusPublished - Jun 2006

Fingerprint

Sister Chromatid Exchange
Tobacco Products
Biomarkers
Smoking
Petrochemical plants
Lymphocytes
1,3-butadiene
Aberrations
Regression analysis
Cytogenetics
Chromosome Aberrations
Carcinogens
Blood
Regression Analysis

Keywords

  • 1,3-butadiene
  • Chromosomal aberrations
  • Occupational exposure
  • Proliferation index
  • Sister chromatid exchanges

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Lack of genotoxic effect in workers exposed to very low doses of 1,3-butadiene. / Lovreglio, Piero; Bukvic, Nenad; Fustinoni, Silvia; Ballini, Andrea; Drago, Ignazio; Foà, Vito; Guanti, Ginevra; Soleo, Leonardo.

In: Archives of Toxicology, Vol. 80, No. 6, 06.2006, p. 378-381.

Research output: Contribution to journalArticle

Lovreglio, P, Bukvic, N, Fustinoni, S, Ballini, A, Drago, I, Foà, V, Guanti, G & Soleo, L 2006, 'Lack of genotoxic effect in workers exposed to very low doses of 1,3-butadiene', Archives of Toxicology, vol. 80, no. 6, pp. 378-381. https://doi.org/10.1007/s00204-005-0046-0
Lovreglio, Piero ; Bukvic, Nenad ; Fustinoni, Silvia ; Ballini, Andrea ; Drago, Ignazio ; Foà, Vito ; Guanti, Ginevra ; Soleo, Leonardo. / Lack of genotoxic effect in workers exposed to very low doses of 1,3-butadiene. In: Archives of Toxicology. 2006 ; Vol. 80, No. 6. pp. 378-381.
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