Lack of on-going adaptations in the soleus muscle activity during walking in patients affected by large-fiber neuropathy

Nazarena Mazzaro, Michael J. Grey, Thomas Sinkjær, Jacob Buus Andersen, Davide Pareyson, Marco Schieppati

Research output: Contribution to journalArticle

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Abstract

The aim of this study was to investigate the contribution of feedback from large-diameter sensory fibers to the adaptation of soleus muscle activity after small ankle trajectory modifications during human walking. Small-amplitude and slow-velocity ankle dorsiflexion enhancements and reductions were applied during the stance phase of the gait cycle to mimic the normal variability of the ankle trajectory during walking. Patients with demyelination of large sensory fibers (Charcot-Marie-Tooth type 1A and antibodies to myelin-associated glycoprotein neuropathy) and age-matched controls participated in this study. The patients had absent light-touch sense in the toes and feet and absent quadriceps and Achilles tendon reflexes, indicating functional loss of large sensory fibers. Moreover, their soleus stretch reflex response consisted of a single electromyographic (EMG) burst with delayed onset and longer duration (P <0.01) than the short- and medium-latency reflex responses observed in healthy subjects. In healthy subjects, the soleus EMG gradually increased or decreased when the ankle dorsiflexion was, respectively, enhanced or reduced. In the patients, the soleus EMG increased during the dorsiflexion enhancements; however, the velocity sensitivity of this response was decreased compared with the healthy volunteers. When the dorsiflexion was reduced, the soleus EMG was unchanged. These results indicate that the enhancement of the soleus EMG is mainly sensitive to feedback from primary and secondary muscle spindle afferents and that the reduction may be mediated by feedback from the group Ib pathways. This study provides evidence for the role of sensory feedback in the continuous adaptation of the soleus activity during the stance phase of human walking.

Original languageEnglish
Pages (from-to)3075-3085
Number of pages11
JournalJournal of Neurophysiology
Volume93
Issue number6
DOIs
Publication statusPublished - Jun 2005

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Ankle
Walking
Skeletal Muscle
Stretch Reflex
Healthy Volunteers
Myelin-Associated Glycoprotein
Muscle Spindles
Sensory Feedback
Achilles Tendon
Touch
Toes
Demyelinating Diseases
Gait
Reaction Time
Reflex
Foot
Tooth
Antibodies

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

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Lack of on-going adaptations in the soleus muscle activity during walking in patients affected by large-fiber neuropathy. / Mazzaro, Nazarena; Grey, Michael J.; Sinkjær, Thomas; Andersen, Jacob Buus; Pareyson, Davide; Schieppati, Marco.

In: Journal of Neurophysiology, Vol. 93, No. 6, 06.2005, p. 3075-3085.

Research output: Contribution to journalArticle

Mazzaro, Nazarena ; Grey, Michael J. ; Sinkjær, Thomas ; Andersen, Jacob Buus ; Pareyson, Davide ; Schieppati, Marco. / Lack of on-going adaptations in the soleus muscle activity during walking in patients affected by large-fiber neuropathy. In: Journal of Neurophysiology. 2005 ; Vol. 93, No. 6. pp. 3075-3085.
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