Abstract
The ability of human recombinant interferon-α2a (IFNα2a) to induce the expression of cyclin-dependent kinase inhibitors p21(waf1) and p27(kip1) consequent to signal transducers and activators of transcription (STAT) protein activation was investigated in six human melanoma cell lines with different susceptibilities to the antiproliferative effect of the cytokine. All the cell lines expressed IFNα and IFNα/β receptors. Exposure for 24 h to IFNα2a markedly enhanced the nuclear expression of STAT1 and STAT2 proteins in all the cell lines. However, no induction of p21(waf1) or p27(kip1) was consistently observed. Overall, results from the study suggest that the induction of such cyclin-dependent kinase inhibitors is not a major mechanism for the antiproliferative effect of IFNα2a, at least in human melanoma cell lines.
| Original language | English |
|---|---|
| Pages (from-to) | 457-463 |
| Number of pages | 7 |
| Journal | Melanoma Research |
| Volume | 9 |
| Issue number | 5 |
| Publication status | Published - 1999 |
Keywords
- Cell growth
- Cyclin-dependent kinases
- Interferon-α2a
- STAT proteins
ASJC Scopus subject areas
- Cancer Research
- Dermatology