Lack of potentiation of anticonvulsant effect by fluoxetine in drug-resistant epilepsy

G. L. Gigli, M. Diomedi, A. Trois, F. Baldinetti, M. G. Marciani, E. Girolami, A. Pasini

Research output: Contribution to journalArticlepeer-review

Abstract

To test the hypothesis that fluoxetine may be a useful adjunct to antiepileptic therapy, we treated with fluoxetine (20-40 mg/day) nine patients suffering from medically intractable epilepsy with daily seizures. Five patients remained unchanged and four worsened. Worsening was more evident at 40 mg/day. One patient improved when receiving the lower dose (20 mg/day) and worsened with the higher dose (40 mg/day). These data suggest: (1) that fluoxetine is not effective as add-on antiepileptic treatment; (2) that caution should be exerted when using fluoxetine as an antidepressive treatment in epileptic patients.

Original languageEnglish
Pages (from-to)221-224
Number of pages4
JournalSeizure
Volume3
Issue number3
Publication statusPublished - 1994

Keywords

  • antidepressive treatment
  • fluoxetine
  • medically intractable epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Psychology(all)

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