Abstract
To test the hypothesis that fluoxetine may be a useful adjunct to antiepileptic therapy, we treated with fluoxetine (20-40 mg/day) nine patients suffering from medically intractable epilepsy with daily seizures. Five patients remained unchanged and four worsened. Worsening was more evident at 40 mg/day. One patient improved when receiving the lower dose (20 mg/day) and worsened with the higher dose (40 mg/day). These data suggest: (1) that fluoxetine is not effective as add-on antiepileptic treatment; (2) that caution should be exerted when using fluoxetine as an antidepressive treatment in epileptic patients.
| Original language | English |
|---|---|
| Pages (from-to) | 221-224 |
| Number of pages | 4 |
| Journal | Seizure |
| Volume | 3 |
| Issue number | 3 |
| Publication status | Published - 1994 |
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Keywords
- antidepressive treatment
- fluoxetine
- medically intractable epilepsy
ASJC Scopus subject areas
- Clinical Neurology
- Pediatrics, Perinatology, and Child Health
- Neurology
- Psychology(all)
Cite this
Gigli, G. L., Diomedi, M., Trois, A., Baldinetti, F., Marciani, M. G., Girolami, E., & Pasini, A. (1994). Lack of potentiation of anticonvulsant effect by fluoxetine in drug-resistant epilepsy. Seizure, 3(3), 221-224.