TY - JOUR
T1 - Lack of prognostic significance of "classic" lobular breast carcinoma
T2 - A matched, single institution series
AU - Viale, Giuseppe
AU - Rotmensz, Nicole
AU - Maisonneuve, Patrick
AU - Orvieto, Enrico
AU - Maiorano, Eugenio
AU - Galimberti, Viviana
AU - Luini, Alberto
AU - Colleoni, Marco
AU - Goldhirsch, Aron
AU - Coates, Alan S.
PY - 2009/9
Y1 - 2009/9
N2 - Whether invasive lobular carcinoma of the breast per se constitutes a prognostically favorable type has been debated. The present series comprises 301 consecutive "classic" lobular breast carcinomas seen at one institution between 1994 and 2001, compared to an equal number of invasive ductal carcinomas at the same institution during the same period, matched for year of surgery, age, menopausal status, primary tumor size, nodal involvement, hormone receptor status and where possible histological grade. Despite matching, the lobular carcinomas were more frequently multifocal, had more involved nodes, lower grade and lower proliferative fraction. There was no significant difference in disease-free or overall survival, locoregional relapse or time to distant metastasis between the lobular and ductal groups overall or within any examined subset, though the lobular group showed a trend to earlier appearance of contralateral breast cancer. Classical lobular histology is not an independent factor in the prognosis of early breast cancer.
AB - Whether invasive lobular carcinoma of the breast per se constitutes a prognostically favorable type has been debated. The present series comprises 301 consecutive "classic" lobular breast carcinomas seen at one institution between 1994 and 2001, compared to an equal number of invasive ductal carcinomas at the same institution during the same period, matched for year of surgery, age, menopausal status, primary tumor size, nodal involvement, hormone receptor status and where possible histological grade. Despite matching, the lobular carcinomas were more frequently multifocal, had more involved nodes, lower grade and lower proliferative fraction. There was no significant difference in disease-free or overall survival, locoregional relapse or time to distant metastasis between the lobular and ductal groups overall or within any examined subset, though the lobular group showed a trend to earlier appearance of contralateral breast cancer. Classical lobular histology is not an independent factor in the prognosis of early breast cancer.
KW - Breast cancer
KW - Lobular carcinoma
KW - Matched study
KW - Prognosis
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UR - http://www.scopus.com/inward/citedby.url?scp=69049113359&partnerID=8YFLogxK
U2 - 10.1007/s10549-008-0112-4
DO - 10.1007/s10549-008-0112-4
M3 - Article
C2 - 18629634
AN - SCOPUS:69049113359
VL - 117
SP - 211
EP - 214
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
SN - 0167-6806
IS - 1
ER -