Lack of prognostic significance of "classic" lobular breast carcinoma: A matched, single institution series

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Abstract

Whether invasive lobular carcinoma of the breast per se constitutes a prognostically favorable type has been debated. The present series comprises 301 consecutive "classic" lobular breast carcinomas seen at one institution between 1994 and 2001, compared to an equal number of invasive ductal carcinomas at the same institution during the same period, matched for year of surgery, age, menopausal status, primary tumor size, nodal involvement, hormone receptor status and where possible histological grade. Despite matching, the lobular carcinomas were more frequently multifocal, had more involved nodes, lower grade and lower proliferative fraction. There was no significant difference in disease-free or overall survival, locoregional relapse or time to distant metastasis between the lobular and ductal groups overall or within any examined subset, though the lobular group showed a trend to earlier appearance of contralateral breast cancer. Classical lobular histology is not an independent factor in the prognosis of early breast cancer.

Original languageEnglish
Pages (from-to)211-214
Number of pages4
JournalBreast Cancer Research and Treatment
Volume117
Issue number1
DOIs
Publication statusPublished - Sep 2009

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Lobular Carcinoma
Breast Neoplasms
Ductal Carcinoma
Histology
Breast
Hormones
Neoplasm Metastasis
Recurrence
Neoplasms

Keywords

  • Breast cancer
  • Lobular carcinoma
  • Matched study
  • Prognosis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

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abstract = "Whether invasive lobular carcinoma of the breast per se constitutes a prognostically favorable type has been debated. The present series comprises 301 consecutive {"}classic{"} lobular breast carcinomas seen at one institution between 1994 and 2001, compared to an equal number of invasive ductal carcinomas at the same institution during the same period, matched for year of surgery, age, menopausal status, primary tumor size, nodal involvement, hormone receptor status and where possible histological grade. Despite matching, the lobular carcinomas were more frequently multifocal, had more involved nodes, lower grade and lower proliferative fraction. There was no significant difference in disease-free or overall survival, locoregional relapse or time to distant metastasis between the lobular and ductal groups overall or within any examined subset, though the lobular group showed a trend to earlier appearance of contralateral breast cancer. Classical lobular histology is not an independent factor in the prognosis of early breast cancer.",
keywords = "Breast cancer, Lobular carcinoma, Matched study, Prognosis",
author = "Giuseppe Viale and Nicole Rotmensz and Patrick Maisonneuve and Enrico Orvieto and Eugenio Maiorano and Viviana Galimberti and Alberto Luini and Marco Colleoni and Aron Goldhirsch and Coates, {Alan S.}",
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T2 - A matched, single institution series

AU - Viale, Giuseppe

AU - Rotmensz, Nicole

AU - Maisonneuve, Patrick

AU - Orvieto, Enrico

AU - Maiorano, Eugenio

AU - Galimberti, Viviana

AU - Luini, Alberto

AU - Colleoni, Marco

AU - Goldhirsch, Aron

AU - Coates, Alan S.

PY - 2009/9

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N2 - Whether invasive lobular carcinoma of the breast per se constitutes a prognostically favorable type has been debated. The present series comprises 301 consecutive "classic" lobular breast carcinomas seen at one institution between 1994 and 2001, compared to an equal number of invasive ductal carcinomas at the same institution during the same period, matched for year of surgery, age, menopausal status, primary tumor size, nodal involvement, hormone receptor status and where possible histological grade. Despite matching, the lobular carcinomas were more frequently multifocal, had more involved nodes, lower grade and lower proliferative fraction. There was no significant difference in disease-free or overall survival, locoregional relapse or time to distant metastasis between the lobular and ductal groups overall or within any examined subset, though the lobular group showed a trend to earlier appearance of contralateral breast cancer. Classical lobular histology is not an independent factor in the prognosis of early breast cancer.

AB - Whether invasive lobular carcinoma of the breast per se constitutes a prognostically favorable type has been debated. The present series comprises 301 consecutive "classic" lobular breast carcinomas seen at one institution between 1994 and 2001, compared to an equal number of invasive ductal carcinomas at the same institution during the same period, matched for year of surgery, age, menopausal status, primary tumor size, nodal involvement, hormone receptor status and where possible histological grade. Despite matching, the lobular carcinomas were more frequently multifocal, had more involved nodes, lower grade and lower proliferative fraction. There was no significant difference in disease-free or overall survival, locoregional relapse or time to distant metastasis between the lobular and ductal groups overall or within any examined subset, though the lobular group showed a trend to earlier appearance of contralateral breast cancer. Classical lobular histology is not an independent factor in the prognosis of early breast cancer.

KW - Breast cancer

KW - Lobular carcinoma

KW - Matched study

KW - Prognosis

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