Lack of prognostic significance of "classic" lobular breast carcinoma: A matched, single institution series

Giuseppe Viale, Nicole Rotmensz, Patrick Maisonneuve, Enrico Orvieto, Eugenio Maiorano, Viviana Galimberti, Alberto Luini, Marco Colleoni, Aron Goldhirsch, Alan S. Coates

Research output: Contribution to journalArticlepeer-review


Whether invasive lobular carcinoma of the breast per se constitutes a prognostically favorable type has been debated. The present series comprises 301 consecutive "classic" lobular breast carcinomas seen at one institution between 1994 and 2001, compared to an equal number of invasive ductal carcinomas at the same institution during the same period, matched for year of surgery, age, menopausal status, primary tumor size, nodal involvement, hormone receptor status and where possible histological grade. Despite matching, the lobular carcinomas were more frequently multifocal, had more involved nodes, lower grade and lower proliferative fraction. There was no significant difference in disease-free or overall survival, locoregional relapse or time to distant metastasis between the lobular and ductal groups overall or within any examined subset, though the lobular group showed a trend to earlier appearance of contralateral breast cancer. Classical lobular histology is not an independent factor in the prognosis of early breast cancer.

Original languageEnglish
Pages (from-to)211-214
Number of pages4
JournalBreast Cancer Research and Treatment
Issue number1
Publication statusPublished - Sep 2009


  • Breast cancer
  • Lobular carcinoma
  • Matched study
  • Prognosis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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